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Supplier: PeproTech, Inc.

Description: SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1β protein, produced by an N-terminal truncation of two additional amino acids, after removal of the signal sequence, contains 72 amino acid residues. Recombinant Rat SDF-1β (CXCL12) is an 8.4 kDa protein containing 72 amino acid residues.

Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Murine IL-1α. Anti­Murine IL-1α­specific antibody was purified by affinity chromatography and then biotinylated.

Catalog Number: (10774-880)

Supplier: PeproTech, Inc.

Description: Monoclonal AntibodyProduced in BALB/c x ICR F1-mice immunized with highly pure Recombinant Human sRANK Ligand. Anti­Human sRANK Ligand­specific antibody was purified from cell culture by Protein G affinity chromatography.

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Catalog Number: (76303-664)

Supplier: PeproTech, Inc.

Description: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant Murine VEGF 165 is a 39.0 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

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Catalog Number: (10777-634)

Supplier: PeproTech, Inc.

Description: PeproTech's Human FGF-basic ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human FGF-basic in a sandwich ELISA format.

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Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human MIP-1β (CCL4). Anti­Human MIP-1β (CCL4)­specific antibody was purified by affinity chromatography employing an immobilized Human MIP-1β matrix.

Catalog Number: (76303-588)

Supplier: PeproTech, Inc.

Description: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF 121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant Human VEGF 121 is a 28.4 kDa, disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.

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Catalog Number: (10774-902)

Supplier: PeproTech, Inc.

Description: Monoclonal AntibodyProduced in C3H/HeJ-mice immunized with highly pure Recombinant Human MIP-1α (CCL3). Anti­Human MIP-1α (CCL3)­specific antibody was purified from ascites fluid by SAS precipitation followed by ion exchange chromatography.

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Catalog Number: (76303-796)

Supplier: PeproTech, Inc.

Description: Human IL-31 is a T cell-derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (also known as gp130-like receptor or IL-31RA) and Oncostatin-M receptor (OSMR). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, JAK1, and JAK2 signaling pathways. IL-31-regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant Human IL-31 is a 15.8 kDa protein containing 141 amino acid residues.

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Supplier: PeproTech, Inc.

Description: Produced from sera of goats immunized with highly pure Recombinant Human SDF-1β (CXCL12). Anti­Human SDF-1β (CXCL12)­specific antibody was purified by affinity chromatography and then biotinylated.

Catalog Number: (10771-886)

Supplier: PeproTech, Inc.

Description: The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro . IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. IGF-I LR3 is a recombinant analog of human IGF-I comprised of the complete IGF-I sequence, with an Arginine substitution for the third position Glutamic acid, and a 13 amino acid length N terminus peptide extension. Specifically engineered for higher biological potency Recombinant Human IGF-I LR3 is a 9.1 kDa, single, non-glycosylated polypeptide chain containing 83 amino acid residues.

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Supplier: PeproTech, Inc.

Description: EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-α and VGF (vaccinia virus growth factor). Recombinant Human EGF is a 6.2 kDa globular protein containing 53 amino acid residues, including 3 intramolecular disulfide bonds.

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Catalog Number: (10771-542)

Supplier: PeproTech, Inc.

Description: PeproTech's Human SDF-1α (CXCL12) ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant Human SDF-1α (CXCL12) in a sandwich ELISA format.

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Supplier: PeproTech, Inc.

Description: IL-2 SRECEPTOR ALPHA Polyclonal antibody, Host: Rabbit, Species reactivity: Human, Conjugate: Biotin, Immunogen: CHO cells derived Recombinant Human IL-2 Receptor A, Formulation: Lyophilized, Application: Sandwich ELISA, Western Blot, Size: 50 uG

Supplier: PeproTech, Inc.

Description: ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant Human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.

Supplier: PeproTech, Inc.

Description: Produced from sera of goats immunized with highly pure Recombinant Rat IFN-γ. Anti­Rat IFN-γ­specific antibody was purified by affinity chromatography and then biotinylated.