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Catalog Number: (10748-554)
Supplier: Prosci
Description: LSD1 Antibody: Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing corepressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.


Catalog Number: (89421-272)
Supplier: Prosci
Description: TMEM106B peptide is used for blocking the activity of TMEM106B antibody.


Catalog Number: (77120-570)
Supplier: Prosci
Description: ARMS2 Peptide


Catalog Number: (77122-968)
Supplier: Prosci
Description: ASPN Peptide


Catalog Number: (77121-730)
Supplier: Prosci
Description: NDUFS3 Peptide


Catalog Number: (77128-146)
Supplier: Prosci
Description: GOT1 Peptide


Catalog Number: (10748-704)
Supplier: Prosci
Description: STEAP3 Antibody: The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP4), STEAP3 promotes both iron and copper reduction. STEAP3 is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, suggesting that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells.


Catalog Number: (10749-676)
Supplier: Prosci
Description: 4E-BP1 Antibody: The translation of mRNA in eukaryotic cells is regulated by the presence of amino acids through multiple mechanisms. One such mechanism involves the evolutionarily conserved serine/threonine kinase TOR (Target of rapamycin, also known as mTOR), which regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. One downstream target of TOR is the eukaryotic initiation factor 4E binding protein 1 (4E-BP1) whose phosphorylation prevents its association with eIF4E, preferentially stimulating translation of mRNAs containing long, highly structured 5'-UTRs. Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferationl, at least in part by inhibiting the activity of TOR towards 4E-BP1.


Catalog Number: (76763-162)
Supplier: Prosci
Description: Anti-ARHGAP25 Rabbit Polyclonal Antibody


Catalog Number: (76754-612)
Supplier: Prosci
Description: Anti-CEBPE Rabbit Polyclonal Antibody


Catalog Number: (76754-950)
Supplier: Prosci
Description: Anti-PI4KB Rabbit Polyclonal Antibody


Catalog Number: (76753-218)
Supplier: Prosci
Description: Anti-PTHLH Rabbit Polyclonal Antibody


Catalog Number: (77122-776)
Supplier: Prosci
Description: Anti-LAG3 Mouse Monoclonal Antibody [clone: 1G4]


Catalog Number: (76755-484)
Supplier: Prosci
Description: Anti-PFKFB2 Rabbit Polyclonal Antibody


Catalog Number: (76753-220)
Supplier: Prosci
Description: Anti-MTHFD1 Rabbit Polyclonal Antibody


Catalog Number: (77124-862)
Supplier: Prosci
Description: Anti-CD44 Goat Polyclonal Antibody


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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The original product is no longer available. The replacement shown is available.
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