You Searched For: PROSCI INCORPORATED

Catalog Number: (10750-046)

Supplier: Prosci

Description: GSTP1 Antibody: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism (i.e., the metabolism of environmental mutagens and carcinogens) and may play a role in susceptibility to cancer. More recent experiments have suggested that differential expression of GSTP1 also contributes to the sensitivity of xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders such as Parkinson's disease. CpG island hypermethylation of the GSTP1 promoter leading to the silencing of the GSTP1 gene has also been linked to cancer.

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Catalog Number: (76764-908)

Supplier: Prosci

Description: Anti-MDX-1103 Recombinant Antibody

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Catalog Number: (76760-596)

Supplier: Prosci

Description: Anti-SENP6 Rabbit Polyclonal Antibody

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Catalog Number: (76752-564)

Supplier: Prosci

Description: Anti-OSBP Rabbit Polyclonal Antibody

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Catalog Number: (76761-096)

Supplier: Prosci

Description: Anti-PGRMC1 Rabbit Polyclonal Antibody

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Catalog Number: (77126-420)

Supplier: Prosci

Description: Human Recombinant IgG1 Fc Protein (from HEK293 cells)

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Catalog Number: (77132-512)

Supplier: Prosci

Description: UBE2I Peptide

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Catalog Number: (77130-360)

Supplier: Prosci

Description: Anti-TNFSF14 Mouse Monoclonal Antibody [clone: 8D4]

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Catalog Number: (89420-236)

Supplier: Prosci

Description: MAK10 peptide is used for blocking the activity of MAK10 antibody.

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Catalog Number: (89419-872)

Supplier: Prosci

Description: ACVR1 peptide is used for blocking the activity of ACVR1 antibody.

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Catalog Number: (76010-660)

Supplier: Prosci

Description: ISG15 is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MCH (major histocompatibility complex)-restricted cytotoxicity. Synthesis is stimulated by IFN-alpha or IFN-beta or IFN-omega , but not IFN-gamma . ISG15 expression is also induced by overexpression of interferon regulatory factors that participate in transcriptional regulation of IFN genes, and by influenza B virus. ISG15 is secreted also by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins. The induction of terminal differentiation in human melanoma cells is associated with alterations in ISG15 expression. Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may be responsible for amplifying and directing some of the immunomodulatory effects of IFN-alpha or IFN-beta. ISG15 has has also been shown to function intracellularly as a ubiquitin homolog.

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Catalog Number: (76009-160)

Supplier: Prosci

Description: This gene encodes a highly conserved, putative transmembrane protein. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. This gene is proposed to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. An alternatively spliced transcript variant encoding a substantially different isoform has been described, but its biological validity has not been determined.

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Catalog Number: (10075-434)

Supplier: Prosci

Description: DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein that is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac®.

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Catalog Number: (77133-528)

Supplier: Prosci

Description: Muc19 Peptide

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Catalog Number: (75794-276)

Supplier: Prosci

Description: T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.

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Catalog Number: (77125-798)

Supplier: Prosci

Description: Anti-IFNGR1 Goat Polyclonal Antibody

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