You Searched For: PROSCI INCORPORATED

Catalog Number: (75794-000)

Supplier: Prosci

Description: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.

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Catalog Number: (10099-930)

Supplier: Prosci

Description: Deletions of the 22q11.2 have been associated with a wide range of developmental defects classified under the acronym CATCH 22. The DGCR2 is a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome.

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Catalog Number: (77125-898)

Supplier: Prosci

Description: Anti-PTPRC Mouse Monoclonal Antibody [clone: [F10-89-4]] (PE (Phycoerythrin)-Cy7®)

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Supplier: Prosci

Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.

Catalog Number: (77122-148)

Supplier: Prosci

Description: Anti-AIFM1 Goat Polyclonal Antibody

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Catalog Number: (10113-270)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Immunogen: Cryopyrin antibody was raised against a 13 amino acid synthetic peptide near the C-Terminus of Cryopyrin, Tested Applications: ELISA, Flow Cyt

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Catalog Number: (76763-820)

Supplier: Prosci

Description: Anti-KCND3 Rabbit Polyclonal Antibody

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Catalog Number: (10107-368)

Supplier: Prosci

Description: TCEA1 is necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. TCEA1 has a role in suppression of transient pausing, which is the most important contribution of TCEA1 to elongation from a stall position. TCEA1 fuse to PLAG1 protein which is overexpressed in epithelial, myoepithelial, and mesenchymal-like tumor cells in tumors.

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Catalog Number: (10115-746)

Supplier: Prosci

Description: Polyclonal antibody CD2BP2 Host: Goat Target Species: human immunogen: CD2BP2 antibody was raised against a 13 amino acid synthetic peptide near the N-Terminus of CD2BP2. Application: ELISA, WB, IHC

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Catalog Number: (10103-636)

Supplier: Prosci

Description: TMEM149 is a single-pass type I membrane protein. The exact function of TMEM149 remains unknown.

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Catalog Number: (76008-998)

Supplier: Prosci

Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.

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Catalog Number: (77120-890)

Supplier: Prosci

Description: NOXO1 Peptide

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Catalog Number: (76762-634)

Supplier: Prosci

Description: Anti-Spike Protein Rabbit Monoclonal Antibody [clone: SP422]

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Catalog Number: (76194-812)

Supplier: Prosci

Description: This mAb recognizes a protein of ~50 kDa identified as SOX10. This mAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.

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Catalog Number: (76756-540)

Supplier: Prosci

Description: Anti-GLB1 Rabbit Polyclonal Antibody

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Catalog Number: (76011-458)

Supplier: Prosci

Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

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