You Searched For: PROSCI INCORPORATED

Catalog Number: (10107-712)

Supplier: Prosci

Description: Gonadal dysgenesis in 9p-deleted individuals might be due to combined hemizygosity of DMRT1 and DMRT2.

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Catalog Number: (77131-096)

Supplier: Prosci

Description: APOBEC3D Peptide

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Catalog Number: (10070-646)

Supplier: Prosci

Description: C-kit (CD117,145 kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene c-kit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.

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Catalog Number: (10111-482)

Supplier: Prosci

Description: Nucleobindin, also known as calnuc, participates in Ca2+ storage in the Golgi, as well as in other biological processes that involve DNA-binding and protein-protein interactions.

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Catalog Number: (10069-592)

Supplier: Prosci

Description: Polyclonal, Host: Rabbit, Species Reactivity: Bacteria, Tested Applications: Western blotting

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Catalog Number: (89417-532)

Supplier: Prosci

Description: SCRN1 Antibody: SCRN1 was first identified as a cytosolic protein that is involved in the regulation of exocytosis from peritoneal mast cells. More recent studies have shown that SCRN1 expression is upregulated in gastric cancer cell lines and may possess epitopes that could function as tumor-associated antigens, potentially providing targets for cancer vaccines in the treatment of gastric cancers. Another report indicates that decreased expression of SCRN1 via RNAi expression resulted in significantly lower rates of cell growth in colorectal cancer cell lines, and increased SCRN1 expression in patients with colorectal cancer correlated with poor prognosis, suggesting that SCRN1 may also be involved in the regulation of cell growth and might be useful as a prognostic tool.

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Catalog Number: (76759-458)

Supplier: Prosci

Description: Anti-BMP2 Rabbit Polyclonal Antibody

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Catalog Number: (75791-708)

Supplier: Prosci

Description: The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.

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Catalog Number: (10075-670)

Supplier: Prosci

Description: Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-M is the neurofilament middle or medium molecular weight polypeptide and runs on SDS-PAGE gels at 145-160 kDa, with some variability across species boundaries. Antibodies to NF-M are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-M antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and Alzheimer's disease.

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Catalog Number: (75791-044)

Supplier: Prosci

Description: Tumor necrosis factor ligand superfamily member 9, also known as 4-1BBL, is a member of the the tumor necrosis factor family. It is a 254 amino acids cytokine that is expressed in brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction.

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Catalog Number: (89419-112)

Supplier: Prosci

Description: TLR5 peptide is used for blocking the activity of TLR5 antibody.

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Catalog Number: (10075-436)

Supplier: Prosci

Description: DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein, is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac®.

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Catalog Number: (10116-342)

Supplier: Prosci

Description: Polyclonal antibody MRPL3 Host: Goat Target Species: human immunogen: MRPL3 antibody was raised against a 13 amino acid synthetic peptide near the C-Terminus of MRPL3. Application: ELISA, IHC

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Catalog Number: (10749-300)

Supplier: Prosci

Description: IKK alpha Antibody: Nuclear factor kappa B (NF-kappa B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and bacteria product LPS. NF-kappa B is associated with Ikappa B proteins in the cell cytoplasm, which inhibit NF-kappa B activity. The long-sought Ikappa B kinase (IKK), which phosphorylates Ikappa B, and mediates Ikappa B degradation and NF-kappa B activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKalpha and IKKbeta ;). IKKalpha and IKKbeta ; interact with each other and both are essential for the NF-kappa B activation. IKKalpha specifically phosphorylates Ikappa B-alpha. IKKalpha is expressed in a variety of human tissues.

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Catalog Number: (10068-680)

Supplier: Prosci

Description: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to RB1 protein, in a cell-cycle dependent manner.

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Catalog Number: (10117-242)

Supplier: Prosci

Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: Apolipoprotein B antibody was raised against a 12 amino acid synthetic peptide near the internal region of Apolipoprotein B; Application: ELISA, Western Blot

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