You Searched For: PROSCI INCORPORATED

Catalog Number: (76756-340)

Supplier: Prosci

Description: Anti-MYOT Rabbit Polyclonal Antibody

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Catalog Number: (76011-626)

Supplier: Prosci

Description: This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene.

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Catalog Number: (76749-354)

Supplier: Prosci

Description: Anti-AKT2 Rabbit Polyclonal Antibody

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Catalog Number: (76758-916)

Supplier: Prosci

Description: Anti-PIGR Rabbit Polyclonal Antibody

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Catalog Number: (76756-058)

Supplier: Prosci

Description: Anti-COL10A1 Rabbit Polyclonal Antibody

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Catalog Number: (77134-980)

Supplier: Prosci

Description: Tafazzin Peptide

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Catalog Number: (76756-538)

Supplier: Prosci

Description: Anti-PGAM1 Rabbit Polyclonal Antibody

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Catalog Number: (77131-710)

Supplier: Prosci

Description: Anti-PDCD1LG2 Mouse Monoclonal Antibody [clone: 7C1]

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Catalog Number: (76763-428)

Supplier: Prosci

Description: Anti-CASQ1 Rabbit Polyclonal Antibody

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Catalog Number: (89416-806)

Supplier: Prosci

Description: JPH2 Antibody: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2-null mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.

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Catalog Number: (75792-910)

Supplier: Prosci

Description: Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF-R signaling is essential for B cell development, survival and humoral immune responses.

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Catalog Number: (89417-502)

Supplier: Prosci

Description: FOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity.

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Catalog Number: (10099-938)

Supplier: Prosci

Description: LRRN3 is a single-pass type I membrane protein. It contains 1 fibronectin type-III domain, 1 Ig-like C2-type (immunoglobulin-like) domain and 12 LRR (leucine-rich) repeats. The function of the LRRN3 protein remains unknown.

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Catalog Number: (76763-902)

Supplier: Prosci

Description: Anti-AKR1D1 Rabbit Polyclonal Antibody

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Catalog Number: (10072-328)

Supplier: Prosci

Description: POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging

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Catalog Number: (89415-990)

Supplier: Prosci

Description: IL-31 Antibody: Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.

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