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Supplier: Adipogen

Description: Pentoxifylline (PTX) metabolite. Can be used as reference material. Showed platelet aggregation in whole blood in vitro. Shown to be more effective than PTX in protecting WC/1 murine fibrosarcoma cells from TNF-alpha cytotoxicity and in inhibiting neutrophil superoxide anion production, degranulation (lactoferrin release) and surface expression of the beta-2 integrin CD11b/CD18.

Supplier: Adipogen

Description: Reference compound for the fluorescent (nitric oxide) NO probe DAR-4M.

Catalog Number: (102512-490)

Supplier: Adipogen

Description: Human CD58 is a cell surface glycoprotein with wide distribution on hemopoietic cells and functions as an adhesion molecule mediating a costimulatory signal through CD2. CD58 is attached to the cell surface by either of two forms - transmembrane or GPI.

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Supplier: Adipogen

Description: IkappaBalpha kinase inhibitor. NF-kappaB inhibitor. Potential anti-inflammatory agent. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. NLRP3 inflammasome inhibitor. Reduces ATPase activity of the NLRP3 inflammasome. Inhibits platelet aggregation.

Catalog Number: (102988-432)

Supplier: Adipogen

Description: Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Asialo-ganglioside GM2 is a major neural ganglioside in Tay Sachs and Sandhoff diseases.

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Catalog Number: (102514-592)

Supplier: Adipogen

Description: DLK1 (Protein delta homolog 1; Preadipocyte factor 1; Pref-1) is a regulator of adipocyte differentiation found in serum and urine. DLK1 might be a decoy ligand. Serum or plasma levels of soluble DLK1 affect negatively or positively adipogenesis and control mesenchymal cell fate. DLK1 is frequently upregulated in myelodysplastic syndrome (MDS) patients compared to non-leukemic individuals.

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Supplier: Adipogen

Description: E7080 is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors. It is most potent against VEGFR2(KDR)/VEGFR3(Flt-4), with IC(50) values of 4nM and 5.2nM respectively.

Catalog Number: (102512-072)

Supplier: Adipogen

Description: Human CD16 is a low affinity receptor for complexed IgG and occurs in two distinct forms, as a glycosyl phosphatidyl inositol (GPI) anchored protein in granulocytes and as an integral membrane protein on NK cells and macrophages.

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Catalog Number: (102512-992)

Supplier: Adipogen

Description: Human CD117 (c-kit) is a transmembrane protein with receptor tyrosine kinase capacity and serves as the receptor for steel factor (SLF). CD117 is expressed on almost all hematopoietic progenitor cells and receptor/ligand interaction is crucial for development of hematopoietic stem cells.

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Catalog Number: (102511-826)

Supplier: Adipogen

Description: Human surface membrane bound IgM complexes with a heterodimer of transmembrane proteins of Igalpha and Igbeta (CD79a and CD79b) to form the B cell antigen receptor (BCR). The BCR complex plays an important role in B cell development and activation. The transmembrane region of mIgM is essential for functional BCR complex assembly.

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Catalog Number: (102512-368)

Supplier: Adipogen

Description: Human CD45 is expressed on all cells of hematopoietic origin, except erythrocytes. CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. CD45 plays an essential role in lymphocyte activation.

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Catalog Number: (102511-338)

Supplier: Adipogen

Description: CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

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Catalog Number: (102514-378)

Supplier: Adipogen

Description: ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels.

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Catalog Number: (102513-088)

Supplier: Adipogen

Description: Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation. CD137 is a type I membrane protein and a member of the TNF receptor superfamily. CD137 appears to be important for T cell proliferation and survival and induces monocyte activation.

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Catalog Number: (102981-552)

Supplier: Adipogen

Description: Erythropoietin is the principal hormone involved in the regulation of erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells and the maintenance of a physiological level of circulating erythrocyte mass. It is a glycoprotein produced primarily by the kidney. The biological effects of EPO are mediated by the erythropoietin receptor (Epo R). Genetic variations in EPO is associated with susceptibility to microvascular complications of diabetes type 2 (MVCD2) (including diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease and diabetic neuropathy). It is used for the treatment of anemia and misused as a performance-enhancing drug in endurance athletes.

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Supplier: Adipogen

Description: ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels.