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Catalog Number: (MSPP-10985)

Supplier: Stemcell Technologies

Description: For differentiation of human monocytes into dendritic cells.

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Supplier: Stemcell Technologies

Description: Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma <i>et al.</i>). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau <i>et al.</i>). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).

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Supplier: Stemcell Technologies

Description: Mouse monoclonal IgG1 antibody against human, rhesus, sooty mangabey CD123 (IL-3Rα), PerCP-Cy5.5-conjugated.

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Supplier: Stemcell Technologies

Description: Mouse monoclonal IgM antibody against human, chimpanzee CD66b, PE­conjugated.

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Supplier: Stemcell Technologies

Description: Transforming growth factor (TGF) beta 2 is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. Similar to TGF-β1 and -β3, TGF-β2 signals via serine-threonine kinase type I and II receptors and activates signal transduction via SMAD family proteins, regulating a variety of functions such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism (de Caestecker; Massague; Zuniga <i>et al.</i>). TGF-β2 is important in many developmental processes; for example, mice with TGF-β2 deletions show defects in the development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems (Dunker and Kreiglstein).

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Catalog Number: (MSPP-78096)

Supplier: Stemcell Technologies

Description: Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge-stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto <i>et al.</i>; Westermark and Heldin). PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim <i>et al.</i>). PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto <i>et al.</i>; Sachinidis <i>et al.</i>). It has been shown that PDGF-AB together with 5-Azacytidine (Catalog #72012), induces the conversion of mature bone and fat cells into tissue-regenerative multipotent stem cells (Chandrakanthan <i>et al.</i>).

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Supplier: Stemcell Technologies

Description: Immunomagnetic isolation of untouched human neutrophils.

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Catalog Number: (MSPP-17878)

Supplier: Stemcell Technologies

Description: Column-free immunomagnetic positive selection of human CD14+ cells for HLA analysis.

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Catalog Number: (MSPP-17699)

Supplier: Stemcell Technologies

Description: Immunomagnetic positive selection of human cells with your own mouse IgG1 antibody.

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Catalog Number: (MSPP-01992)

Supplier: Stemcell Technologies

Description: For detection and measurement of human immunoglobulin A.

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Catalog Number: (MSPP-06005)

Supplier: Stemcell Technologies

Description: Cell culture medium for establishment and maintenance of mouse intestinal organoids.

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Supplier: Stemcell Technologies

Description: Interleukin 3 (IL-3) is a species-specific pleiotropic cytokine that promotes the survival and proliferation of pluripotent hematopoietic stem cells and lineage-committed progenitor cells and their differentiation into mature cells of most lineages, including mast cells, basophils, neutrophils, eosinophils, macrophages, dendritic cells, erythrocytes, and megakaryocytes (Fung <i>et al.</i>; Metcalf <i>et al.</i>; Broughton <i>et al.</i>). IL-3 is produced by activated T cells, and has a physiological role in inflammation and allergies by promoting the secretion of inflammatory mediators such as histamine, IL-4, and IL-6 by mast cells, basophils and eosinophils. The mouse IL-3 receptor consists of a unique alpha-subunit (CD123) and two beta subunits, one specific for IL-3 (βIL-3), the other shared with the receptors for IL-5 and GM-CSF (beta common chain, βc or CD131). IL-3 binding to heterodimeric receptors containing the alpha subunit and one of either beta subunits activates JAK/STAT, MAPK, and PI3K signaling pathways (Scott and Begley).

Supplier: Stemcell Technologies

Description: Serum-free medium kit for highly efficient SMAD inhibition-mediated neural induction of human ES and iPS cells.

Catalog Number: (MSPP-19848)

Supplier: Stemcell Technologies

Description: Immunomagnetic isolation of untouched mouse pan-naïve T cells

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Catalog Number: (MSPP-10970)

Supplier: Stemcell Technologies

Description: Human T cell activation and expansion reagent. 1×2 ml vial.

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Supplier: Stemcell Technologies

Description: Immunomagnetic positive selection of human CD4+ cells (e.g. CD4+ T cells).

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