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Description: This antibody recognizes a doublet of 50 kDa and a single band of 42 kDa identified as cyclin E. Cyclin proteins are a family of related proteins, which control the progression of the eukaryotic cell cycle. Overexpression of cyclin E shortens the length of the G1 phase, accelerating progression of S phase. The activity of cyclin E is mediated through its activation of cyclin dependent kinase 2 (CDK2) protein and is modulated by the presence of tumor suppressor proteins such as P16.
Catalog Number: 76633-548
Supplier: Diagnostic Biosystems


Description: Monoclonal anti-smooth muscle myosin reacts with myosin heavy chain polypeptides of 200 and 204 kDa. It does not react with skeletal, cardiac, or non-muscle myosin. In immunohistochemistry it stains vascular and visceral smooth muscle cells and cells that have smooth muscle-like characteristics.
Catalog Number: 76633-978
Supplier: Diagnostic Biosystems


Description: This antibody reacts with a nuclear antigen present in proliferating human cells. It can be used to evaluate the Ki-67 labeling index in various tumors.
Catalog Number: 95025-066
Supplier: Diagnostic Biosystems


Description: This antibody is specific against an epitope located on the β chain (i.e., in S-100a and S-100b) but not on the α chain of S-100 (i.e., in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.
Catalog Number: 76634-340
Supplier: Diagnostic Biosystems


Description: This antibody reacts with a 34 kDa protein known as calponin. Calponin, a calmodulin, binds tropomyosin and F-actin and is thought to be involved in the regulation of smooth muscle contraction. Expression of calponin is restricted to smooth muscle cells. Two isoforms of calponin exist whose molecular weights are 34 kDa and 29 kDa. 29 kDa isoform is primarily restricted to the muscle of the urogenital tract.
Catalog Number: 76633-716
Supplier: Diagnostic Biosystems


Description: This antibody is specific to a cell surface glycoprotein of 80 to 95 kDa, known as CD44. CD44 is expressed on the surface of lymphocytes, monocytes and granulocytes. This antibody reacts with red cells pretreated with 2-Aminoethyl Isothiouronium Bromide (AET).
Catalog Number: 76633-530
Supplier: Diagnostic Biosystems


Description: This antibody reacts with a 55 kDa protein. Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response in insulin and IGF-1 induced signaling. GLUT-1 is detectable in many human tissues including those of the colon, lung, stomach, esophagus and breast. GLUT-1 immunoreactivity in some cancers, including trans-carcinoma of the urinary bladder, has been associated with aggressive behavior.
Catalog Number: 76635-144
Supplier: Diagnostic Biosystems


Description: This antibody reacts with a 49 kDa protein. At least five CD1 genes are identified (CD1a, b, c, d and e). This antibody reacts with cortical thymocytes, Langerhans cells in epidermis, dendritic cells of dermis and Langerhans cells of mucosa of tonsil. This antibody may be useful in the characterization of leukemias and lymphomas.
Catalog Number: 76634-448
Supplier: Diagnostic Biosystems


Description: Clone number 6F-H2, Wilms' Tumor (WT1), is a gene involved in the induction of Wilms? tumor, a pediatric renal malignancy. Wilms' tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system.
Catalog Number: 95024-886
Supplier: Diagnostic Biosystems


Description: This antibody is specific to 34 kDa protein known as myogenin. Myogenin is a member of family of myogenic regulatory genes which includes MyoD, myf5 and MRF4. These genes encode a set of transcription factors which are essential for muscle development. Expression of myogenin is restricted to cells of skeletal muscle origin.
Catalog Number: 99990-602
Supplier: Diagnostic Biosystems


Description: This antibody is a member of a family of complex antigens, which also includes non-specific cross-reacting antigens (NCA). This antibody stains specific regions of CEA. It reacts with colorectal adenocarcinomas but does not show any staining with polymorphonuclear neutrophils and erythrocytes.
Catalog Number: 76633-104
Supplier: Diagnostic Biosystems


Description: This antibody reacts with a 70 kDa protein. COX-2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters and cytokines that induce its expression. COX-2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX-1 levels remained unchanged.
Catalog Number: 95024-978
Supplier: Diagnostic Biosystems


Description: This antibody is specific to α-smooth muscle isoform of actin. It reacts with smooth muscle cells of vessels and different parenchymes.
Catalog Number: 76633-346
Supplier: Diagnostic Biosystems


Description: Calbindin D28K and Calretinin (also designated CR or 29 kDa Calbindin) are two closely related intracellular calcium-binding proteins belonging to the Troponin-C superfamily. Initially isolated from chick retina. Calretinin is an intracellular calcium-binding protein belonging to the troponin C superfamily characterized by a structural motif described as the EF-hand domain. The immunohistochemical detection of calretinin in developing cerebellum is restricted to the later stages indicated by weak staining from week 21 of gestation in Purkinje and basket cells and in neurons of the dentate nucleus. The intensity of staining increases as the cerebellum matures. In tumors, calretinin has been detected in mesotheliomas and some pulmonary adenocarcinomas.
Catalog Number: 76634-236
Supplier: Diagnostic Biosystems


Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.
Catalog Number: 76634-554
Supplier: Diagnostic Biosystems


Description: GATA3 binding protein 3 or GATA3, is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types. The human GATA3 gene has been mapped to chromosome 10p15. GATA =3 expression is primarily seen in breast carcinoma and urothelial carcinoma. Anti-GATA3 can also be useful in the identification of unknown primary carcinoma when carcinomas of the breast or bladder are a possibility.
Catalog Number: 76634-540
Supplier: Diagnostic Biosystems


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