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Image Unavailable-75931-434

Anti-RANBP10 Rabbit Polyclonal Antibody

Catalog Number: (75931-434)
Supplier: Rockland Immunochemical
Description: The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.
Image Unavailable-75931-498

Anti-REEP2 Rabbit Polyclonal Antibody

Catalog Number: (75931-498)
Supplier: Rockland Immunochemical
Description: Mammalian odorant receptors require accessory proteins such as RTP1 and RTP2 for functional cell surface expression. Receptor expression-enhancing protein (REEP) family members are transmembrane proteins which interact with odorant receptor proteins and may enhance the odorant receptor responses to odorants. Recently studies have shown other chemosensory receptors such as bitter taste receptors are also influenced by RTP and REEP family members.
Product Image-75933-180

Anti-TSC2 Rabbit Polyclonal Antibody

Catalog Number: (75933-180)
Supplier: Rockland Immunochemical
Description: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. At least three isoforms of TSC2 exist.
Image Unavailable-75930-090

Mouse (Virus Free) Plasma Non Sterile In Sodium Citrate, Rockland Immunochemicals

Catalog Number: (75930-090)
Supplier: Rockland Immunochemical
Description: Non-Sterile Plasma in Anticoagulant
Image Unavailable-75932-564

Anti-TAF9 Rabbit Polyclonal Antibody

Catalog Number: (75932-564)
Supplier: Rockland Immunochemical
Description: Initiation of transcription by RNA polymerase II is coordinated by the transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and the TBP-associated factors (TAFs). TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation (1). TAF9 is one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16 (2).
Image Unavailable-75928-352

Hamster Blood In Heparin Sodium, Rockland Immunochemicals

Catalog Number: (75928-352)
Supplier: Rockland Immunochemical
Description: Hamster Blood In Heparin Sodium
Product Image-10800-832

Anti-CLDN1 Rabbit Polyclonal Antibody

Catalog Number: (10800-832)
Supplier: Rockland Immunochemical
Description: Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer. Characterization of Claudins expression in human tumors can be an additional diagnostic tool. Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3. Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.
Image Unavailable-75928-344

Hamster (Golden Syrian) Buffy Coat Preparation, Rockland Immunochemicals

Catalog Number: (75928-344)
Supplier: Rockland Immunochemical
Description: Hamster (Golden Syrian) Buffy Coat Preparation
Image Unavailable-75934-422

Goose Plasma Non-Sterile In Potassium EDTA, Rockland Immunochemicals

Catalog Number: (75934-422)
Supplier: Rockland Immunochemical
Description: Non-Sterile Plasma in Anticoagulant
Image Unavailable-75933-452

Anti-UPK1B Rabbit Polyclonal Antibody

Catalog Number: (75933-452)
Supplier: Rockland Immunochemical
Description: Uroplakin-1B (UPK1B) is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. UPK1B is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins and may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
Product Image-75930-936

Anti-PIAS4 Rabbit Polyclonal Antibody

Catalog Number: (75930-936)
Supplier: Rockland Immunochemical
Description: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS4. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS4 interacts with p53 and blocks its ability to induce Bax and p21 transcription. PIAS4 is also important in the control of the ubiquitin-dependent proteasomal degradation of the Ets-1 transcription factor. PIAS4 has been implicated in the DNA-damage response pathway and is thought to work in combination with PIAS1 for the productive association of 53BP1, BRCA1 and RNF168.
Image Unavailable-75931-906

SIRT1

Catalog Number: (75931-906)
Supplier: Rockland Immunochemical
Description: SIRT1 control protein-GST fusion
Image Unavailable-75931-874

Anti-SIDT2 Rabbit Polyclonal Antibody

Catalog Number: (75931-874)
Supplier: Rockland Immunochemical
Description: The SID1 transmembrane family member (SIDT2) is a highly glycosylated, multipass transmembrane protein that localizes to the lysosomal membrane. SIDT2 is highly expressed in liver, brain and kidney, with no or little expression in skeletal muscles, heart or other tissues. Little is known of the function of SIDT2.
Image Unavailable-RL2001656S

Anti-PFKM Goat Polyclonal Antibody (Biotin)

Catalog Number: (RL2001656S)
Supplier: Rockland Immunochemical
Description: Anti-Fructose-6-Phosphate Kinase (Rabbit Muscle) (Goat) Antibody Biotin Conjugated - Anti-Fructose-6-Phosphate Kinase Antibody Has Been Tested For Use In ELISA, Immunofluorescence Microscopy And Western Blot.
Image Unavailable-76262-894

Anti-MAPK3 Rabbit Polyclonal Antibody (DL680)

Catalog Number: (76262-894)
Supplier: Rockland Immunochemical
Description: ERK1 antibodies detect the ERK1 isoform. Mitogen activiated protein kinase 3, also known as MAPK3, ERK, or ERK1, is an integral component of the MAP kinase cascade that regulates cell growth and differentiation. ERK1 and ERK2 are activated by MEK1 and MEK2 in the B-raf signaling pathway resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Human ERK1 and ERK2 are 84% identical in sequence and share common functionality in cells. Anti-ERK1 antibody is ideal for investigators involved in Neuroscience, Cell Signaling and Cancer Research.
Image Unavailable-75930-162

Anti-STXBP1 Rabbit Polyclonal Antibody

Catalog Number: (75930-162)
Supplier: Rockland Immunochemical
Description: Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin. Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex. The function of Munc18-1 is thought to be regulated by phosphorylation. Munc18-1 pS241 Antibody is ideal for researchers interested in neuroscience research.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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The original product is no longer available. The replacement shown is available.
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