You Searched For: OPTEM

Catalog Number: (100245-092)

Supplier: Southern Biotechnology

Description: Rabbit F(ab')2 Anti-Rat IgG(H+L)-FITC antibody with minimal reactivity to human proteins for use in flow cytometry and immunocytochemistry assays.

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Supplier: Southern Biotechnology

Description: The CD23 antigen is the low affinity IgE Fc receptor, which is a 45-49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells) and can also be found on the surface of T cells, macrophages and platelets. It is distinct from the high affinity IgE receptors found on basophils and mast cells which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a “membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

Catalog Number: (103264-490)

Supplier: Southern Biotechnology

Description: FITC Anti-Mouse IgG1 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

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Catalog Number: (100245-384)

Supplier: Southern Biotechnology

Description: Feline CD5, a member of the scavenger receptor family of cell surface receptors, is a type I transmembrane glycoprotein that is expressed on most thymocytes and mature T lymphocytes. CD5 is thought to function in both cell-cell recognition and signal transduction. The monoclonal antibody f43 is useful as a pan T cell marker.

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Catalog Number: (100244-208)

Supplier: Southern Biotechnology

Description: Goat F(ab')2 Anti-Human Ig-PE antibody for use in flow cytometry assays.

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Catalog Number: (100245-184)

Supplier: Southern Biotechnology

Description: Rabbit Anti-Rat IgG(H+L)-FITC antibody for use in immunohistochemistry and western blotting assays.

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Catalog Number: (100244-792)

Supplier: Southern Biotechnology

Description: Goat F(ab')2 Anti-Rabbit IgG(H+L)-AP antibody with minimal reactivity to mouse and human proteins for use in ELISA, immunohistochemistry / immunocytochemistry, and western blotting assays.

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Catalog Number: (103264-944)

Supplier: Southern Biotechnology

Description: Rabbit F(ab')2 Anti-Goat IgG(H+L)-FITC antibody with minimal reactivity to human serum proteins for use in ELISA, flow cytometry, and western blotting assays.

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Catalog Number: (100245-708)

Supplier: Southern Biotechnology

Description: Low Endotoxin/Azide Free Anti-Human IgG Fc antibody for use in ELISA, flow cytometry, western blotting, ELISpot, and multiplex assays.

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Catalog Number: (101442-838)

Supplier: Southern Biotechnology

Description: CY5 Anti-Rat IgM antibody for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.

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Supplier: Southern Biotechnology

Description: Protein G, Buffer Formulation Supplied lyophilized from distilled water; No BSA, preservatives or amine-containing buffer salts added, Store at -20 deg C, Applications: ELISA, Size: 1.0 mg

Catalog Number: (100243-022)

Supplier: Southern Biotechnology

Description: CD106, also known as VCAM-1, is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (e.g., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein. The M/K-2 monoclonal antibody immunoprecipitates a peptide that gives a single band on SDS-PAGE gels with an apparent Mr of ~100 kDa under reducing conditions and 92 kDa under non-reducing conditions.

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Supplier: Southern Biotechnology

Description: ZAP-70 is a protein tyrosine kinase (PTK) with the primary role of catalyzing the phosphorylation of tyrosine residues in cellular proteins, and thus, contributes significantly to the initiation of cell signaling. ZAP-70 is normally expressed on T cell and NK cells.

Supplier: Southern Biotechnology

Description: VLA-4 belongs to the β1-integrin family, which functions both as cell-matrix and cell-cell receptors. As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/Pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive. Antibody PS/2 also reacts with human VLA-4.

Supplier: Southern Biotechnology

Description: CD56, an isoform of the neural cell adhesion molecule (NCAM), is a heavily glycosylated type I transmembrane protein. On human hematopoietic cells its expression is restricted to NK cells and a subpopulation of T lymphocytes (known as large granular lymphocytes) which demonstrate natural killer activity. While it is clear that NCAM plays a role in homotypic adhesion of neuronal cells, the significance of CD56 expression on NK cells is not clear and remains controversial.

Catalog Number: (100245-684)

Supplier: Southern Biotechnology

Description: AP Anti-Human IgG Fc antibody for use in ELISA, immunohistochemistry, and western blotting assays.

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