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Catalog Number: (103265-410)
Supplier: Southern Biotechnology
Description: CD45, also known as the leukocyte common antigen (LCA), exists as four different isoforms (180, 190, 205, 220 kDa) that are generated by alternative splicing of three exons. LCA is found on all cells of hematopoietic origin, except erythrocytes and platelets. CD45 expression is required for T cell and B cell antigen receptor-mediated activation.


Catalog Number: (100244-382)
Supplier: Southern Biotechnology
Description: Goat Anti-Human Lambda-Biotin antibody for use in ELISA, flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, and ELISpot assays.


Catalog Number: (100245-198)
Supplier: Southern Biotechnology
Description: Rabbit Anti-Rat IgG(H+L)-HRP antibody with minimal reactivity to human proteins for use in ELISA and immunohistochemistry assays.


Catalog Number: (103265-122)
Supplier: Southern Biotechnology
Description: Purified Sheep Anti-Rat IgG(H+L) antibody for use in ELISA assays.


Catalog Number: (100245-914)
Supplier: Southern Biotechnology
Description: CD19 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is expressed at all stages of B cell differentiation except terminally differentiated plasma cells. It is also present on the cell surface of follicular dendritic cells. CD19 associates with CD21, CD81, Leu 13 and/or MHC Class II molecules to form a signal transduction complex on the B cell surface. This signaling complex modulates the activation threshold for the B cell antigen receptor (BCR).


Catalog Number: (100244-592)
Supplier: Southern Biotechnology
Description: PE Anti-Rat IgG1 antibody for use in flow cytometry assays.


Catalog Number: (100246-252)
Supplier: Southern Biotechnology
Description: CD42b, also known as GPIbα, is a two-chain membrane glycoprotein that forms a noncovalent complex with CD42a (GPIX) on the surface of platelets and megakaryocytes. Binding of the GPIb/GPIX heterodimer to von Willebrand factor bound to exposed subendothelial surfaces is essential for platelet adhesion at sites of injury.


Catalog Number: (100242-454)
Supplier: Southern Biotechnology
Description: Goat F(ab’)2 Anti-Mouse IgM-Biotin antibody with minimal reactivity to human proteins for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.


Catalog Number: (100244-160)
Supplier: Southern Biotechnology
Description: CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107a is principally expressed in epithelial cells and macrophages in a variety of organs in normal and beige mutant mice. It may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases.


Catalog Number: (100243-604)
Supplier: Southern Biotechnology
Description: CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and epidermal growth factor-like domains. It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes. In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.


Catalog Number: (100243-252)
Supplier: Southern Biotechnology
Description: CD18 represents the common β2 integrin subunit that associates non-covalently with the α/β chains of CD11a, CD11b, and CD11c to form various integrin heterodimers. It is expressed strongly on lymphocytes and monocytes and weakly on granulocytes. CD18 mediates a variety of heterotypic and homotypic intercellular adhesion reactions and it regulates the ligand-binding activates of the various CD11/CD18 complexes. The monoclonal antibody C71/16 has not been reported to inhibit cell adhesion.


Catalog Number: (100244-320)
Supplier: Southern Biotechnology
Description: Goat Anti-Human IgA-Texas Red antibody for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.


Catalog Number: (100243-428)
Supplier: Southern Biotechnology
Description: The lymphocyte Fcγ receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fcγ type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying FcγR+ cells, monoclonal antibodies to the FcγII/III receptor have been used to block Fc receptor binding of IgG, Fc-mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on FcγR for parasitic invasion. The monoclonal antibody 93 recognizes a conformational epitope formed by FcγII and FcγIII receptors.


Catalog Number: (100244-282)
Supplier: Southern Biotechnology
Description: Goat Fab Anti-Human IgG-AP antibody for use in ELISA assays.


Catalog Number: (100242-296)
Supplier: Southern Biotechnology
Description: Purified Anti-Human IFN-gamma antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, ELISA, ELISpot, immunoprecipitation, and multiplex assays.


Catalog Number: (100244-360)
Supplier: Southern Biotechnology
Description: Goat F(ab')2 Anti-Human Kappa-PE antibody for use in flow cytometry assays.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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