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Catalog Number: (103264-536)
Supplier: Southern Biotechnology
Description: CD4 is a type I transmembrane glycoprotein expressed on most thymocytes and the helper/inducer subpopulation of mature T lymphocytes of all mouse strains tested. CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic lymphoid precursors. The CD4 antigen functions as a co-receptor, interacting with class II major histocompatability complex (MHC) molecules in the recognition of foreign antigens by T cells. In vivo and in vitro treatment with the GK1.5 monoclonal antibody effectively depletes CD4+ cells. GK1.5 also blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.


Catalog Number: (101442-562)
Supplier: Southern Biotechnology
Description: Purified Swine IgG for use as a control in flow cytometry assays and as a standard in ELISA.


Catalog Number: (100243-632)
Supplier: Southern Biotechnology
Description: Murine CD72.1 (Lyb-2.1), a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 which is distributed on all T cells and a small number of B cells. The 10.1.D2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface which leads to inhibition of the positive signal resulting from CD5/CD72 pairing. However, 10.1.D2 can itself trigger a positive signal by binding CD72.


Catalog Number: (103259-784)
Supplier: Southern Biotechnology
Description: Goat Anti-Mouse IgG2a-FITC antibody for use in immunohistochemistry / immunocytochemistry and western blotting assays.


Catalog Number: (103265-144)
Supplier: Southern Biotechnology
Description: Protein G, Buffer Formulation Supplied lyophilized from distilled water; No BSA, preservatives or amine-containing buffer salts added, Store at -20 deg C, Conjugate: Hrp, Applications: ELISA, Size: 1.0 mL


Catalog Number: (100242-424)
Supplier: Southern Biotechnology
Description: Goat Anti-Mouse IgM-HRP antibody for use in ELISA, immunohistochemistry / immunocytochemistry, western blotting, and ELISpot assays.


Catalog Number: (103265-370)
Supplier: Southern Biotechnology
Description: The BC96 monoclonal antibody reacts with human CD25, the 55 kDa interleukin-2 receptor α chain (IL-2Rα). CD25 is expressed by early progenitors of T and B lineage as well as by activated mature T and B lymphocytes. By itself, CD25 binds IL-2 only with low affinity. However, CD25 associates with CD122 (IL-2 receptor β chain) and CD132 (common γ chain) to form the high affinity IL-2 receptor. CD25 plays a role in lymphocyte differentiating and activation/proliferation. CD25 is expressed on activated B cells, monocytes/macrophages, and T cells.


Catalog Number: (103264-884)
Supplier: Southern Biotechnology
Description: Goat Anti-Rabbit IgG(H+L)-AP antibody with minimal reactivity to mouse, rat, and human proteins for use in ELISA assays.


Catalog Number: (103264-692)
Supplier: Southern Biotechnology
Description: FITC Anti-Hamster IgG1 antibody for use in flow cytometry assays.


Catalog Number: (100242-672)
Supplier: Southern Biotechnology
Description: Purified Goat Anti-Mouse IgG2a antibody with minimal reactivity to human proteins for use in ELISA, flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, ELISpot, and purification assays.


Catalog Number: (100244-596)
Supplier: Southern Biotechnology
Description: FITC Anti-Rat IgG2a antibody for use in flow cytometry and immunohistochemistry assays.


Catalog Number: (100245-364)
Supplier: Southern Biotechnology
Description: 1.0mg.


Catalog Number: (103264-466)
Supplier: Southern Biotechnology
Description: Goat Anti-Mouse IgG3-Biotin antibody with minimal reactivity to human, bovine, and horse serum proteins for use in ELISA assays.


Supplier: Southern Biotechnology
Description: CD45, also known as the leukocyte common antigen (LCA), exists as four different isoforms (180, 190, 205, 220 kDa) that are generated by alternative splicing of three exons. LCA is found on all cells of hematopoietic origin, except erythrocytes and platelets. CD45 expression is required for T cell and B cell antigen receptor-mediated activation.

Catalog Number: (103260-066)
Supplier: Southern Biotechnology
Description: Porcine CD3ε is a member of the T-cell receptor-associated CD3 complex. It is found on a subpopulation of thymocytes and on all pig T lymphocytes. The monoclonal antibody PPT3 is mitogenic when presented to peripheral blood mononuclear cells in immobilized form.


Catalog Number: (103264-634)
Supplier: Southern Biotechnology
Description: The CD45 antigen is an essential regulator of leukocyte activation and development and is now known to be a protein tyrosine phosphatase, e.g., CD45 is able to dephosphorylate the Src family of protein kinases. This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling, and Fc receptor stimulation. The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants (CD45R; see companion products 1660, 1665, 1675, 1685, and 1820) and as allelic forms CD45.1 (Ly-5.1) and CD45.2 (Ly-5.2). The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. The monoclonal antibody A20 recognizes all mouse leukocytes expressing the CD45.1 allotype.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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