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Description: This antibody recognizes a protein doublet of 20-22 kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75960-458

Supplier: Biotium

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Description: This antibody recognizes a protein doublet of 20-22 kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75960-552

Supplier: Biotium

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Description: MART-1 / Melan-A, Monoclonal antibody, Clone: M2-9E3, Host: Mouse, Species reactivity: Mouse, Dog, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF680R, Immunogen: Recombinant hMART-1 protein, Synonyms: Antigen LB39-AA, Application: IF, IHC Western, Size: 500uL

Catalog Number: 75960-532

Supplier: Biotium

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Description: MCAM / MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: MCAM/1101, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: purified, Immunogen: Recombinant human MCAM protein, Application: Immunofluorescence, Flow cytometry, Size: 500uL

Catalog Number: 75960-662

Supplier: Biotium

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Description: MHC I, Monoclonal antibody, Clone: 108-2C5, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405M, Immunogen: Normal human peripheral blood lymphocytes, Synonyms: HLA-A; HLA class 1A; MHC class I HLA-A, Application: Immunofluorescence, Flow, Size: 100uL

Catalog Number: 75960-754

Supplier: Biotium

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Description: MHC II (HLA-DP), Monoclonal antibody, Clone: Bra-14, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Human REH cells, Application: Immunofluorescence, Immunohistology (formalin), Flow cytometry, Size: 500uL

Catalog Number: 75960-936

Supplier: Biotium

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Description: MHC II (HLA-DP), Monoclonal antibody, Clone: Bra-14, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Human REH cells, Application: Immunofluorescence, Immunohistology (formalin), Flow cytometry, Size: 100uL

Catalog Number: 75960-934

Supplier: Biotium

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Description: MHC II (HLA-DP), Monoclonal antibody, Clone: Bra-14, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Human REH cells, Application: Immunofluorescence, Immunohistology (formalin), Flow cytometry, Size: 100uL

Catalog Number: 75960-962

Supplier: Biotium

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Description: MHC II (HLA-DRA), Monoclonal antibody, Clone: IPO-10, Host: Mouse, Species reactivity: Human, Monkey, Isotype: IgM, kappa, Conjugate: CF488A, Immunogen: Spleen cells of a patient with hairy cell leukemia (Daudi cells), Application: Immunofluorescence, Flow, Size: 500uL

Catalog Number: 75960-826

Supplier: Biotium

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Description: MHC II (HLA-DQ), Monoclonal antibody, Clone: SPV-L3, Host: Mouse, Species reactivity: Human, Pig, Isotype: IgG2a, kappa, Conjugate: purified, Immunogen: T4-positive CTL clone HG-38, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Catalog Number: 75961-052

Supplier: Biotium

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Description: MHC II (HLA-DRA), Monoclonal antibody, Clone: 19-26.1, Host: Mouse, Species reactivity: Human, Monkey, Isotype: IgM, kappa, Conjugate: CF647, Immunogen: Spleen cells of a patient with hairy cell leukemia (Daudi cells), Application: Immunofluorescence, Flow, Size: 100uL

Catalog Number: 75961-160

Supplier: Biotium

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Description: This antibody recognizes a protein of 40-45 kDa, identified as human milk fat globule membrane protein (HMFG). HMFG is present on normal human breast epithelial cells and cell lines derived from breast carcinomas, as well as to the outer surface of the human milk fat globule. HMFG is considered as a differentiation marker. It is useful as specific breast epithelial marker and can also provide a tool to study the role of the cell surface in normal and neoplastic mammary development.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75961-282

Supplier: Biotium

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Description: Milk Fat Globulin, Monoclonal antibody, Clone: MFG-06, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, BSA-free, Immunogen: Human milk fat globule membrane preparation, Synonyms: HMFG; Lactadherin, Application: IF, Size: 50 uL

Catalog Number: 75961-378

Supplier: Biotium

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Description: MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. This MAb recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75961-596

Supplier: Biotium

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Description: MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. This MAb recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi.

Catalog Number: 75961-586

Supplier: Biotium

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Description: MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. This MAb recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Catalog Number: 75961-600

Supplier: Biotium

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