You Searched For: Securimed SAS

Description: Produced in <i>E. coli</i>. Contains 126/252 amino acids.

Catalog Number: 76288-438

Supplier: Enzo Life Sciences

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Description: Binimetinib is a potent inhibitor of MEK1/2 with an IC50 of 12 nM in a cell-free assay.

Catalog Number: 76203-118

Supplier: Enzo Life Sciences

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Description: Host: Mouse, Isotype: IgG1

Catalog Number: 89165-056

Supplier: Enzo Life Sciences

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Description: Alpha-crystallins composed of alpha A (~20 kDa) and alpha B (~20 kDa) subunits, are major water-soluble proteins accounting for almost 50% of total protein in the mammalian transparent eye lens and they are also found in a variety of other tissues. The two other crystallin families, beta and gamma, are homologous to each other but not to the alpha family or the sHsp's. Alpha-crystallins are also referred to as small heat shock proteins, since they are induced by increased temperature in a variety of organisms. The alpha-crystallins have sequence homology as well as structural and functional similarities with the small Hsp's such as Hsp25/27. Most small heat shock proteins have four common structural and functional features: (i) molecular weight between 12 and 43kDa; (ii) the formation of large oligomeric complexes composed of alphaA-crystallin, alphaB-crystallin and Hsp25/27; (iii) the moderately conserved alpha-crystallin domain in the central region of the protein; and (iv) molecular chaperone activity. The alpha-crystallin domain comprises approximately 90 residues, is bounded by variable N-terminal and C-terminal extensions and is involved in oligomer assembly. Oligomers can reach 800kDa or more and are dynamic, exhibiting subunit exchanges and organizational plasticity, possibly leading to functional diversity. Phosphorylation of serine residues occurs during development and in response to stress, and usually decreases oligomer size. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation, although productive release and refolding of denatured proteins requires close cooperation with other chaperones. Other proposed functions include a role in membrane stabilization and modulation of intermediate filament organization during physiological stress and neurodegenerative disease.

Catalog Number: 200062-518

Supplier: Enzo Life Sciences

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Description: Increased sensitivity standard PCR mix for a broader range of samples, with enhanced speed, yield, and specificity.

Catalog Number: 10014-624

Supplier: Enzo Life Sciences

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Description: Protein kinase substrate

Catalog Number: 89161-152

Supplier: Enzo Life Sciences

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Catalog Number: 89160-312

Supplier: Enzo Life Sciences

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Description: The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TLR8 gene contains three exons, two of which have coding function. TLR8 cDNA codes for a protein of approximate molecular weight of 120kDa.

Catalog Number: 89154-152

Supplier: Enzo Life Sciences

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Description: Recommended Applications: Flow Cytometry

Species reactivity: Human, Dog

Catalog Number: 76002-854

Supplier: Enzo Life Sciences

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Description: Activates PPAR alpha and the phospholipase C (PLC) signalling pathway

Catalog Number: 89149-078

Supplier: Enzo Life Sciences

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Description: BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. BCMA plays an important role in B cell development, function and regulation.

Catalog Number: 10049-596

Supplier: Enzo Life Sciences

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Description: Produced in <i>E. coli</i>. Dimer of two identical subunits (119 aa) linked together by very strong hydrophobic interactions.

Catalog Number: 89151-660

Supplier: Enzo Life Sciences

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Description: Shikonin inhibits TNF-α- and B6 melanoma-induced angiogenesis in mice. It blocks expression of integrin αvβ3 and inhibits endothelial cell proliferation and migration in vitro.

Catalog Number: 89157-266

Supplier: Enzo Life Sciences

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Description: Recombinant monclonal antibody (Rabbit IgGκ).

Recommended Applications: Flow Cytometry, IHC (FS), IP, WB, FUNC

Catalog Number: 76284-812

Supplier: Enzo Life Sciences

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Description: Biosynthesis via 15-OH prostaglandin dehydrogenase from lung and liver microsomes and by a nonenzymatic process.

Catalog Number: 89160-194

Supplier: Enzo Life Sciences

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Description: rSec6 and rSec8 are rat homologs of the yeast Sec6 and Sec8 proteins that are essential for protein transport between the Golgi apparatus and the plasma membrane. In yeast, Sec8 is part of a 19.5S complex that includes Sec6 and Sec15, that also associate with the ras-like GTP binding protein Sec4. An analogous 17S complex in rat brain was found to contain rSec6 and rSec8, along with eight proteins with a combined molecular weight of 743 kDa. The membrane-associated rSec6/8 complex co-immunoprecipitates with syntaxin, providing evidence that this complex is involved in synaptic vesicle docking and fusion at the presynaptic terminal.

Catalog Number: 89142-314

Supplier: Enzo Life Sciences

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