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Description: For the quantitative determination of soluble human CD14 in serum, plasma and cell culture medium.

Catalog Number: 10049-632

Supplier: Enzo Life Sciences

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Description: Cell permeable modulator of Ins(1,4,5)-P3-induced Ca2+ release. A prototype drug for a group of structurally related calcium channel blockers in human platelets. Has been shown, in the absence of other stimuli, to activate TRPV1, V2 and V3, but not TRPV4, V5 and V6 expressed in HEK 293 cells. Potentiates the effect of capsaicin, protons and heat on TRPV1. It was originally introduced as an IP3 receptor blocker and subsequently as an inhibitor of store-operated Ca2+ entry (75µM).

Catalog Number: 89150-650

Supplier: Enzo Life Sciences

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Description: Host: Mouse, Isotype: IgG2b

Catalog Number: 89165-678

Supplier: Enzo Life Sciences

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Description: Lipid dye

Catalog Number: 89166-054

Supplier: Enzo Life Sciences

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Description: Produced in <i>E. coli</i>.

Catalog Number: 89165-466

Supplier: Enzo Life Sciences

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Description: Host: Rabbit

Catalog Number: 89162-264

Supplier: Enzo Life Sciences

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Description: Cell cycle inhibitor

Catalog Number: 89150-508

Supplier: Enzo Life Sciences

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Description: For the quantitative determination of 11-dehydro-TXB2 in culture supernatants and urine from any species

Catalog Number: 89141-140

Supplier: Enzo Life Sciences

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Description: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface, and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites, increasing the predicted MW from 200kDa to ~600kDa. The diagram shown indicates the domain structure and functional regions of agrin, as well as domains required for AChR aggregation and alpha-dystroglycan and heparin binding.  Various agrin isoforms are generated by alternative splicing at the X, Y and Z sites, and differ in the presence or absence of small inserts. The isoforms can determine the biological activity of agrin and their expression in specific tissues and stages of development. While no difference in functional activity has been detected between splicing variants at site X, insertion of a 4 aa peptide at site Y modestly increases agrins nAChR clustering activity. Insertion of an 8 aa peptide at splicing site Z increases the clustering activity of soluble rat agrin 10,000 fold.

Catalog Number: 200061-664

Supplier: Enzo Life Sciences

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Description: Inhibitor of PP1 and PP2A

Catalog Number: 89148-892

Supplier: Enzo Life Sciences

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Description: Produced in yeast.

Catalog Number: 89144-350

Supplier: Enzo Life Sciences

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Description: Immunoglobulin M (IgM) is an immunoglobulin expressed initially on the surface of B-cells as a monomer of two mu heavy chains and two light chains. Following B-cell activation, IgM is secreted in its pentameric form, consisting of five IgM molecules joined at the base of the Fc domain by a J chain. IgM is the first Immunoglobulin expressed following infection.

Catalog Number: 89142-028

Supplier: Enzo Life Sciences

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Description: Ultra-pure; inhibits actin polymerization

Catalog Number: 89164-968

Supplier: Enzo Life Sciences

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Description: The 90 kDa molecular chaperone family includes 90 kDa heat shock protein Hsp90 and 94 kDa glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum. Mammalian cells express inducible Hsp90 alpha and constitutive Hsp90 beta isoforms that are encoded by separate genes. The amino acid sequences of human and yeast Hsp90 alpha are 85% and 90% homologous to those of Hsp90 beta, respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions containing independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular protein in most cells. Hsp90 functions as part of the cell's powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by non-physiological conditions. In the absence of stress, however, Hsp90 provides a necessary component of such fundamental cellular processes as hormone signaling and cell cycle control by serving as a chaperone for many key signaling molecules including steroid receptors, cell cycle kinases involved in signal transduction, and p53. As many of these client proteins are known oncogenes, Hsp90 inhibitors such as 17-AAG, a geldanamycin analog, have been of benefit in the treatment of many cancers.

Catalog Number: 89135-328

Supplier: Enzo Life Sciences

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Description: Tyrosine kinase inhibitor

Catalog Number: 89148-904

Supplier: Enzo Life Sciences

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Description: Host: Mouse, Isotype: IgG1

Catalog Number: 89162-310

Supplier: Enzo Life Sciences

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