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Catalog Number: (10049-534)
Supplier: Enzo Life Sciences
Description: Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.


Supplier: Enzo Life Sciences
Description: TCP-1alpha is a 60 kDa subunit of a cytosolic hetero-oligomer chaperone that is known to be involved in the folding of Actin and Tubulin. This protein is a member of the Chaperonin family, which includes E. coli GroEL, the mitochondrial Heat-shock protein Hsp60, the plastid Rubisco-subunit-binding protein, and the archaebacterial protein TF55. These Chaperonins assist the folding of proteins upon ATP hydrolysis.

Catalog Number: (89158-486)
Supplier: Enzo Life Sciences
Description: Chelator that can induce differentiation in tumor cells.


Catalog Number: (76285-034)
Supplier: Enzo Life Sciences
Description: Recombinant monclonal antibody (Human IgG1κ).

Recommended Applications: Flow Cytometry, FUNC


Supplier: Enzo Life Sciences
Description: SIRT inhibitor

Supplier: Enzo Life Sciences
Description: Produced in <i>E. coli.</i> A non-glycosylated protein containing 137 amino acids.

Catalog Number: (89155-444)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG1


Catalog Number: (76201-836)
Supplier: Enzo Life Sciences
Description: Recombinant monoclonal antibody


Catalog Number: (76003-380)
Supplier: Enzo Life Sciences
Description: Produced in E.coli.


Supplier: Enzo Life Sciences
Description: The PathoGene® HPV Type 16/18 Probe is a mixture of biotin-labeled HPV 16 and HPV 18-specific probes in buffered formamide and hybridization enhancers.

SDS

Catalog Number: (95046-108)
Supplier: Enzo Life Sciences
Description: Hsp 110 belongs to a family of large stress proteins known as the Hsp110/SSE family, the mostly overlooked relatives of the well studied Hsp70 family. Members of this group, while significantly larger and containing sequences not present in the Hsp70 family, share 30-33% amino acid identity with members of the Hsp70 family, mostly in the conserved ATP-binding domain. Presently, all identified members of the Hsp70-like sequences belong to either the Hsp70 family or the Hsp110/SSE family. Hsp110 appears to be a normal constituent of mammalian cells with highest expression in the brain, and its induction by heat shock strongly correlates with cellular thermotolerance. Hsp110 may contribute to RNA stability, and its capacity to bind peptide has made Hsp110 a promising immunoadjuvant in anti-tumor vaccine development.


Supplier: Enzo Life Sciences
Description: Cell permeable inhibitor of the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α or okadaic acid through inhibition of IκBα degradation.

Catalog Number: (76002-534)
Supplier: Enzo Life Sciences
Description: Modulator of embryogenesis and known effector of tissue development and morphogenesis


Supplier: Enzo Life Sciences
Description: Stable analog of endogenous S-nitroso compounds. Nitric oxide (NO) donor and a source of NO in vivo which spontaneously releases NO under physiological conditions. The half-life time is 4.6 hours in aqueous media.

Catalog Number: (89161-292)
Supplier: Enzo Life Sciences
Description: Negative control for IKK-NBD peptide


Supplier: Enzo Life Sciences
Description: Cyclooxygenase inhibitor. Selectively inhibits PGH synthase-2 (IC50=1 µM) with no inhibition of PGH synthase-1 at concentrations up to 100 µM. Protects neuronal cultures from LPS-induced neurotoxicity.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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