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Image Unavailable-76003-438

Human Recombinant Carbonic anhydrase 9

Catalog Number: (76003-438)
Supplier: Enzo Life Sciences
Description: Produced in HEK 293 cells.
Product Image-89155-906

APO-BRDU™ kit, TUNEL Assay

Catalog Number: (89155-906)
Supplier: Enzo Life Sciences
Description: Kit for measuring apoptosis with high sensitivity by Dual Color Flow Cytometry in mammalian cells. Br-dUTP is more readily incorporated into the genome of apoptotic cells than are larger ligands like fluorescein, biotin, etc. This greater incorporation coupled with the use of a fluorescein labelled anti-BrdU monoclonal antibody (Prod. No. ALX-804-197L) gives rise to a stronger signal in flow cytometry.
Product Image-89164-002

Human Recombinant Tau-352 (0N3R variant) (from E. coli)

Catalog Number: (89164-002)
Supplier: Enzo Life Sciences
Description: Produced in E. coli.
Product Image-89165-872

Lyso-ID® Red Detection Kit (GFP-CERTIFIED®), Enzo Life Sciences

Supplier: Enzo Life Sciences
Description: For use with GFP-expressing cell lines, as well as cells expressing blue, cyan or yellow fluorescent proteins.

SDS

Product Image-95043-790

Anti-HMOX1 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: Enzo Life Sciences
Description: Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

SDS

Product Image-89142-268

Human Native HSP90 (from HeLa cells)

Supplier: Enzo Life Sciences
Description: Produced in HeLa cells.

Product Image-89151-140

CMH hydrochloride ≥99%

Supplier: Enzo Life Sciences
Description: Spin trapping reagent.

Product Image-89152-606

(Z)-4-Hydroxytamoxifen ≥98%

Supplier: Enzo Life Sciences
Description: Tamoxifen metabolite

Product Image-89158-176

PD 98059 ≥95% (by HPLC)

Catalog Number: (89158-176)
Supplier: Enzo Life Sciences
Description: PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems. Inhibits cell growth and proliferation in acute myelogenous leukemia cell lines by causing cell arrest.
Product Image-89164-574

N,N-Dimethylsphingosine, D-erythro ≥98% (by TLC)

Supplier: Enzo Life Sciences
Description: Sphingosine kinase inhibitor

Image Unavailable-89160-000

Cp 31398 Dihydrochloride (synthetic) ≥98% (by TLC)

Supplier: Enzo Life Sciences
Description: CP-31398 restores mutant p53 tumor suppressor function in vitro without affecting p53 homologs p63 and p73, and in vivo inhibiting UVB-induced skin carcinogenesis in mice. Stabilization of p53 inhibits ubiquitination without altering phosphorylation at Ser12 or Ser20 or MDM2 binding. Administration of this or similar compounds has the potential to enhance cytotoxic chemotherapy.

Image Unavailable-76003-070

Simvastatin sodium salt ≥97% (by HPLC)

Supplier: Enzo Life Sciences
Description: Competitive inhibitor of HMG-CoA reductase

Product Image-101410-454

Anti-SMAC/DIABLO Mouse Monoclonal Antibody

Catalog Number: (101410-454)
Supplier: Enzo Life Sciences
Description: Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate.
Image Unavailable-10001-806

NUCLEAR-ID® ≥95% (by HPLC), CELLESTIAL® blue DNA stain

Catalog Number: (10001-806)
Supplier: Enzo Life Sciences
Description: Cell permeable DNA stain that can be used for a wide range of applications

SDS


Image Unavailable-89149-310

Chlortetracycline hydrochloride ≥80%

Catalog Number: (89149-310)
Supplier: Enzo Life Sciences
Description: Protein synthesis inhibitor
Product Image-89153-934

Anti-SNCA Rat Monoclonal Antibody

Supplier: Enzo Life Sciences
Description: Synuclein was originally identified in Torpedo californica as a small neuroprotein that localized to the nuclear envelope of neurons and to presynaptic nerve termini. The human homolog was initially termed NACP, a precursor protein to NAC (Non-Ab Component), because of its prevalence in amyloid plaques in Alzheimer’s patients. Later, NACP was recognized as being alpha-Synuclein (alpha-SYN), a 14kDa protein, belonging to the synuclein family of phosphoproteins that also includes: betalpha-SYNuclein, gammalpha-SYNuclein, and synoretin.
alpha-SYN is recognized as a key component in the development and diagnosis of neurodegenerative synucleinopathic diseases (NSDs), such as Alzheimer’s and Parkinson’s disease. In the past five years, several genetic and post-translational modifications to alpha-SYN have been elucidated that have been linked to its collaboration in the formation of the classical Lewy bodies (LBs) or Lewy neurites that are associated with neurodegeneration. A study that shed more light on the neurogenesis of autorecessive synucleinopathies (ARSs) was the finding that alpha-SYN accumulation can occur due to mutations in the E3 ubiquitin ligase.
ARSs only account for a small percentage of NSD. Thus the illustration that alpha-SYN has a high susceptibility to tyrosine nitration may be the key component in understanding the formation of LBs. Due to the chemical structure of alpha-SYN, tyrosine nitration readily leads to the formation of oligomers via covalent O,O’-dityrosine bonds (cross-linking). Nitrosylated, wild-type, alpha-SYN products thus form SDS-insoluble, heat-stable aggregates in vitro that may account for alpha-SYN inclusions in all forms of NSDs.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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