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Catalog Number: (10368-188)
Supplier: Bioss
Description: The Raf family of serine/threonine specific kinases is comprised of three members (aRaf, bRaf, and cRaf) that play a critical role in regulating cell growth and differentiation, and couple growth factor receptor stimulation to nuclear transcription factors via the Ras/mitogen activated protein kinase (MAPK) pathway. cRaf kinase (also known as Raf1) is a small GTPase like kinase of 73 kDa, and is a signal transducer of multiple extracellular stimuli that is regulated by several pathways, and that once activated, phosphorylates MEK which in turn phosphorylates ERK. Raf1 is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is part of the Ras dependent signaling pathway from receptors to the nucleus.


Catalog Number: (10411-204)
Supplier: Bioss
Description: The Raf kinases are important intermediates in signal transduction. Raf protein family members, including A Raf and B Raf, have intrinsic serine/threonine kinase activity. Interaction between Ras proteins and Raf proteins results in Raf-mediated phosphorylation and activation of MEK (also known as MAP kinase kinase). Defects in BRAF are involved in a wide range of cancers. B-Raf is a serine/threonine protein kinase that acts as a signal transducer from membrane-associated receptors to nuclear transcription factors. 1 BRAF is important for the regulation of cell proliferation and determination of cell fate during embryogenesis. BRAF acts downstream of Ras and upstream of MEK in the Ras-Raf-MEK-ERK signal transduction pathway, which is a conserved RAS-activated protein kinase cascade that regulates cell growth, proliferation, and differentiation in response to growth factors, cytokines, and hormones.


Catalog Number: (10368-210)
Supplier: Bioss
Description: The Raf family of serine/threonine specific kinases is comprised of three members (aRaf, bRaf, and cRaf) that play a critical role in regulating cell growth and differentiation, and couple growth factor receptor stimulation to nuclear transcription factors via the Ras/mitogen activated protein kinase (MAPK) pathway. cRaf kinase (also known as Raf1) is a small GTPase like kinase of 73 kDa, and is a signal transducer of multiple extracellular stimuli that is regulated by several pathways, and that once activated, phosphorylates MEK which in turn phosphorylates ERK. Raf1 is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is part of the Ras dependent signaling pathway from receptors to the nucleus.


Catalog Number: (10368-184)
Supplier: Bioss
Description: The Raf family of serine/threonine specific kinases is comprised of three members (aRaf, bRaf, and cRaf) that play a critical role in regulating cell growth and differentiation, and couple growth factor receptor stimulation to nuclear transcription factors via the Ras/mitogen activated protein kinase (MAPK) pathway. cRaf kinase (also known as Raf1) is a small GTPase like kinase of 73 kDa, and is a signal transducer of multiple extracellular stimuli that is regulated by several pathways, and that once activated, phosphorylates MEK which in turn phosphorylates ERK. Raf1 is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is part of the Ras dependent signaling pathway from receptors to the nucleus.


Catalog Number: (76967-426)
Supplier: ANTIBODIES.COM LLC
Description: Anti-Iba1 Mouse Recombinant Monoclonal Antibody [clone: rAIF1/1909]


Catalog Number: (76702-084)
Supplier: AFG BIOSCIENCE LLC
Description: Human tumor Necrosis Factor Associated Factor 1 (TRAF1) ELISA Kit


Supplier: STILLA TECHNOLOGIES, INC.
Description: Assay-specific crystal flex probes and primers for the detection of BRAF/KRAS/NRAS mutations and its positive control. The BRAF/KRAS/NRAS Crystal Digital PCR® assay is a 10X assay designed to detect and quantify mutations in BRAF, KRAS, and NRAS genes using the ruby chip. BRAF, KRAS, and NRAS genes are pivotal in regulating cell signaling pathways implicated in cancer development.

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Catalog Number: (75815-580)
Supplier: Transgenomic
Description: Transgenomic’s ICEme Kit is an in vitro assay that uses multiplexed PCR (MX PCR) followed by multiplexed ICE COLD-PCR (MX-ICP) for amplification and enrichment of mutations in KRAS Exons 2, 3 and 4, NRAS Exons 2, 3 and 4, BRAF Exons 11 and 15, PIK3CA Exons 9 and 20, EGFR Exons 12, 18, 19, 20 and 21.


Catalog Number: (220020-931)
Supplier: R&D Systems
Description: Anti-RAF1 Mouse Monoclonal Antibody [clone: 563002]


Catalog Number: (10691-466)
Supplier: Abnova
Description: Mouse monoclonal antibody raised against recombinant BRAF.


Catalog Number: (10578-070)
Supplier: Abnova
Description: BRAF monoclonal antibody (M08), clone 3F5, Mouse monoclonal antibody raised against a partial recombinant BRAF, Size: 100ug


Catalog Number: (10169-010)
Supplier: Genetex
Description: Mouse monoclonal antibody [4G4] to Raf1


Catalog Number: (10578-066)
Supplier: Abnova
Description: BRAF monoclonal antibody (M06), clone 3A6, Mouse monoclonal antibody raised against a partial recombinant BRAF, Size: 100ug


Catalog Number: (10578-074)
Supplier: Abnova
Description: BRAF monoclonal antibody (M10), clone 1H7, Mouse monoclonal antibody raised against a partial recombinant BRAF, Size: 100ug


Supplier: STILLA TECHNOLOGIES, INC.
Description: Assay-specific Crystal Flex Probes and primers for the detection of BRAF mutations and its Positive Control. BRAF (V600, V600E) Crystal Digital PCR® Assay is a 10X assay designed to detect and quantify 1 mutation in the BRAF gene using the Ruby Chip. BRAF is pivotal in regulating cell signaling pathways implicated in cancer development, notably melanoma, colorectal cancer and thyroid cancer, through its role in the MAPK/ERK pathway. Mutations in BRAF, particularly the V600E mutation, lead to uncontrolled cell proliferation and survival.

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Catalog Number: (10169-020)
Supplier: Genetex
Description: Mouse monoclonal antibody [4G4] to Raf1


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