You Searched For: bra30

Catalog Number: (10263-306)

Supplier: Bioss

Description: Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss. SCA is caused by the expansion of a translated CAG repeat, encoding a polyglutamine tract in SCA gene products, known as ataxins. The ataxin proteins are ubiquitously expressed in nervous tissue, but are primarily detected in cerebellum, brain stem and spinal cord in the central nervous system. Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.

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Catalog Number: (103282-952)

Supplier: Novus Biologicals

Description: The BEX2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to BEX2. This antibody reacts with human. The BEX2 Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry-Paraffin.

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Catalog Number: (10251-150)

Supplier: Bioss

Description: Dbx1 homeodomain transcription factor is expressed in progenitors at the boundary between the dorsal and ventral plates of the caudal neural tube, from which postmitotic cells migrate tangentially to their final destination. Dbx1 is implicated in patterning the central nervous system during embryogenesis. Cell fate allocation and cell diversity are determined at very early stages in progenitor cells at precise coordinates along the dorsoventral and anteroposterior axis. In the spinal cord, the spatially restricted expression of Dbx1 in progenitors is critical in establishing interneuron cell fates and helps coordinate diverse phenotypic features. In the telencephalon, Dbx1 is expressed in restricted progenitor domains at the borders of the developing pallium.

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Catalog Number: (103393-936)

Supplier: Novus Biologicals

Description: The BNP Antibody (11G4) from Novus Biologicals is a mouse monoclonal antibody to BNP. This antibody reacts with human. The BNP Antibody (11G4) has been validated for the following applications: Western Blot, Immunohistochemistry.

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Supplier: VWR International

Description: Bead beating is the most effective and verstile lysis method available.

Supplier: Biotium

Description: S100, Monoclonal antibody, Clone: 4C4.9, Host: Mouse, Species reactivity: Mouse, Cow, Rat, Human, Isotype: IgG2a, kappa, Conjugate: purified, Immunogen: Purified bovine brain S100 protein, Synonyms: Bpb; NEF; S100-A1; S100 Alpha Chain, Application: IF, IHC (formalin), Size: 500uL

Supplier: Biotium

Description: S100, Monoclonal antibody, Clone: 4C4.9, Host: Mouse, Species reactivity: Mouse, Cow, Rat, Human, Isotype: IgG2a, kappa, Conjugate: CF660R, Immunogen: Purified bovine brain S100 protein, Synonyms: Bpb; NEF; S100-A1; S100 Alpha Chain, Application: IF, IHC Western, Size: 100uL

Supplier: Biotium

Description: S100, Monoclonal antibody, Clone: 4C4.9, Host: Mouse, Species reactivity: Mouse, Cow, Rat, Human, Isotype: IgG2a, kappa, Conjugate: CF594, Immunogen: Purified bovine brain S100 protein, Synonyms: Bpb; NEF; S100-A1; S100 Alpha Chain, Application: IF, IHC Western, Size: 100uL

Catalog Number: (103271-180)

Supplier: Novus Biologicals

Description: The CCDC88B Antibody from Novus Biologicals is a rabbit polyclonal antibody to CCDC88B. This antibody reacts with human. The CCDC88B Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.

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Catalog Number: (10304-476)

Supplier: Bioss

Description: The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morpho-genesis (1-4). Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity (5,6). The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including catenin b, to regulate cadherin function (7). BR-cadherin (for brain-cadherin, also designated cadherin-12 or N-cadherin 2) is expressed specifically in neurons in the central nervous system and is thought to be involved in neuronal development (8).

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Catalog Number: (10251-148)

Supplier: Bioss

Description: Dbx1 homeodomain transcription factor is expressed in progenitors at the boundary between the dorsal and ventral plates of the caudal neural tube, from which postmitotic cells migrate tangentially to their final destination. Dbx1 is implicated in patterning the central nervous system during embryogenesis. Cell fate allocation and cell diversity are determined at very early stages in progenitor cells at precise coordinates along the dorsoventral and anteroposterior axis. In the spinal cord, the spatially restricted expression of Dbx1 in progenitors is critical in establishing interneuron cell fates and helps coordinate diverse phenotypic features. In the telencephalon, Dbx1 is expressed in restricted progenitor domains at the borders of the developing pallium.

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Supplier: Biotium

Description: S100, Monoclonal antibody, Clone: 4C4.9 + S100A1/1012, Host: Mouse, Species reactivity: Mouse, Cow, Rat, Human, Isotype: IgG2a, kappa, Conjugate: CF488A, Immunogen: Purified bovine brain S100 protein, Synonyms: Bpb; NEF; S100-A1; S100 Alpha Chain, Application: IF, Size: 100uL

Catalog Number: (10251-146)

Supplier: Bioss

Description: Dbx1 homeodomain transcription factor is expressed in progenitors at the boundary between the dorsal and ventral plates of the caudal neural tube, from which postmitotic cells migrate tangentially to their final destination. Dbx1 is implicated in patterning the central nervous system during embryogenesis. Cell fate allocation and cell diversity are determined at very early stages in progenitor cells at precise coordinates along the dorsoventral and anteroposterior axis. In the spinal cord, the spatially restricted expression of Dbx1 in progenitors is critical in establishing interneuron cell fates and helps coordinate diverse phenotypic features. In the telencephalon, Dbx1 is expressed in restricted progenitor domains at the borders of the developing pallium.

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Supplier: Biotium

Description: S100, Monoclonal antibody, Clone: 4C4.9 + S100A1/1012, Host: Mouse, Species reactivity: Mouse, Cow, Rat, Human, Isotype: IgG2a, kappa, Conjugate: CF405S, Immunogen: Purified bovine brain S100 protein, Synonyms: Bpb; NEF; S100-A1; S100 Alpha Chain, Application: IF, Size: 100uL

Catalog Number: (10261-224)

Supplier: Bioss

Description: The homeobox is DNA sequence that is approximately 180 base pairs long that is involved in all steps of the developmental regulation of animals, fungi and plants, from embryogenesis to cell differentiation. The homeobox encodes a protein domain of about 60 amino acids, called the homeodomain, that can bind to DNA. The gastrulation brain homeobox 1 (GBX1) gene, along with another homeobox gene (EN2), maps to chromosome 7q36, and is expressed in septal and pallidal areas and in the basal forebrain cholinergic system, an area implicated in Alzheimer’s disease. The GBX1 gene encodes the GBX1 protein, which localizes to the nucleus and contains 1 homeobox DNA-binding domain.

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Catalog Number: (10782-372)

Supplier: Biosensis

Description: BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post Translation Modification (PTM): The propeptide is N-glycosylated and glycosulfated. PTM: Converted into mature BDNF by plasmin (PLG) (By similarity). DISEASE: Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. SIMILARITY: Belongs to the NGF-beta family.

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