You Searched For: bra30

Catalog Number: (10395-426)

Supplier: Bioss

Description: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

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Catalog Number: (76118-256)

Supplier: Bioss

Description: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.Predominantly expressed in muscle and brain.

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Catalog Number: (75793-652)

Supplier: Prosci

Description: Nucelobindin-2 (NUCB2; Nesfatin-1) was first isolated in adipocytes, but is also expressed by gastric mucosa and pancreatic beta cells. This pattern of nucleobindin-2 expression, as well as the presence of nucelobindin-2 within the plasma of rodents and humans, strongly suggests that this compound may act as a circulating regulatory factor. Nucelobindin-2 is reported to reduce food intake after administration. It is responsible for regulating appetite and production of body fat. Excess nucelobindin-2 in the brain leads to a loss of appetite, lack of nesfatin-1 in the brain leads to an increase of appetite.

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Catalog Number: (76173-432)

Supplier: Boster Biological Technology

Description: Polyclonal antibody for Neuregulin 1/NRG1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. Neuregulin 1/NRG1 information: Molecular Weight: 70392 MW; Subcellular Localization: Pro-neuregulin-1, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Does not seem to be active; Tissue Specificity: Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific.

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Catalog Number: (76120-942)

Supplier: Bioss

Description: Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1-4), each with a core transmembrane segment domain and a C-terminal 120 amino-acid cyclic nucleotide-binding domain motif. HCN channels are expressed in the brain, heart, thalamus and testis. The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart. HCN3 contains a segment characterized by a series of positively charged amino acids at every third position. This region designated S4 is likely to be the voltage sensor of the protein. In the brain, HCN3 and HCN4 exhibit subcortical distribution mainly concentrated in the hypothalamus and thalamus, respectively.

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Catalog Number: (76172-970)

Supplier: Boster Biological Technology

Description: Polyclonal antibody for Calretinin/CALB2 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. Calretinin/CALB2 information: Molecular Weight: 31540 MW; Tissue Specificity: Brain.

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Catalog Number: (10101-756)

Supplier: Prosci

Description: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

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Catalog Number: (10472-548)

Supplier: Bioss

Description: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).Tissue specificity:Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.

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Catalog Number: (10270-172)

Supplier: Bioss

Description: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.

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Catalog Number: (10801-946)

Supplier: Rockland Immunochemical

Description: Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons.

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Catalog Number: (RL112-401-C81)

Supplier: Rockland Immunochemical

Description: Anti-GABA(A) Receptor gamma 2 (Rabbit) antibody is suitable for use in Western Blotting and IHC. Expect a band of approximately 46kDa in size corresponding 2-subunit of the GABAA receptor in Western blots of Rat brain extracts.

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Catalog Number: (75793-650)

Supplier: Prosci

Description: Nucelobindin-2 (NUCB2; Nesfatin-1) was first isolated in adipocytes, but is also expressed by gastric mucosa and pancreatic beta cells. This pattern of nucleobindin-2 expression, as well as the presence of nucelobindin-2 within the plasma of rodents and humans, strongly suggests that this compound may act as a circulating regulatory factor. Nucelobindin-2 is reported to reduce food intake after administration. It is responsible for regulating appetite and production of body fat. Excess nucelobindin-2 in the brain leads to a loss of appetite, lack of nesfatin-1 in the brain leads to an increase of appetite.

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Catalog Number: (10423-208)

Supplier: Bioss

Description: FGF20 is secreted heparin binding growth factor that is a member of the FGF family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion by promoting cellular proliferation and differentiation. The gene for FGF20 was shown to be expressed in normal brain, particularly the cerebellum. FGF20 signals through the FGFR 2c and 3c and is expressed during limb and brain development.

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Catalog Number: (89365-190)

Supplier: Genetex

Description: CCKB receptor, also called gastrin receptor, is a Cholecystokinin Receptor. CCKB receptor binds both sulfated and non-sulfated cholecystokinin analogs. This receptor regulates anxiety, arousal, opiate-induced analgesia, and gastric-acid secretion. CCKB receptor has been reported in brain, colon, pancreas, stomach, thyroid, and various cancers. ESTs have been isolated from normal eye libraries and libraries derived from cancers of the brain, embryo, germ cell, lung, and placenta.

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Supplier: Biosensis

Description: The Biosensis NGF Rapid™ enzyme-linked immunosorbent assay (ELISA) kit is a sandwich ELISA that allows the quantification of mouse NGF in less than 3 hours in cell culture supernatants and brain extracts only if used as directed.

Catalog Number: (10270-440)

Supplier: Bioss

Description: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.

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