Supplier: Biotium

Description: Eukaryotic histones are basic and water-soluble nuclear proteins. They form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.

Supplier: Biotium

Description: Anti-IgG Rabbit Polyclonal Antibody (CF™ 633)

Supplier: Biotium

Description: CD27Monoclonal antibody, Clone: 203.6, Host: Mouse, Conjugate: CF405S, Species reactivity: Human, Isotype: IgG3, kappa, Immunogen: Sezary cells, Synonyms: T14, TNFRSF7, TNFSF7, Tp55, Application: IF, FC, Size: 500 uL

Supplier: Biotium

Description: Transgelin / SM22-alphA, Monoclonal antibody, Clone: TAGLN/247, Host: Mouse, Species reactivity: Pig, Cow, Human, Rabbit, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recombinant full-length human transgelin (TAGLN) protein, Application: IF, Size: 100uL

Supplier: Biotium

Description: CD28 Monoclonal antibody, Clone: 204.12, Host: Mouse, Species reactivity: Mouse, Pig, Cow, Sheep, Human, Isotype: IgG2a, K, Conjugate: CF594, Immunogen: Stimulated human leucocytes, Synonyms: T-cell-specific surface glycoprotein CD28, Application: IF, Size: 100uL

Catalog Number: (89139-102)

Supplier: Biotium

Description: Biotin-11-CTP (Biotin-11-cytidine-5′-triphosphate, tetralithium salt) can be enzymatically incorporated into RNA. The number 11 is the number of atoms in the linker between biotin and CTP.

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Supplier: Biotium

Description: Thyroglobulin, Monoclonal antibody, Clone: TGB04 + TGB05, Host: Mouse, Species reactivity: Mouse, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Human thyroid follicular cells, Synonyms: AITD3, Application: Immunohistology (formalin), Flow, Size: 500uL

Supplier: Biotium

Description: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium

Description: Cytokeratin 18 Monoclonal antibody, Clone: KRT18/1190, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Recom human KRT18 protein, Synonyms: K18, Application: IF, IHC, FC, Size: 500 uL

Supplier: Biotium

Description: CD50 Monoclonal antibody, Clone: 101-1D2, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: purified, Immunogen: Stimulated human leukocytes, Synonyms: ICAMR, Intercellular adhesion molecule 3, Application: IF, Immunohistology, Size: 100uL

Supplier: Biotium

Description: Blue Fluorescent Cf405M (Ex/Em 408/452 Nm) Is Spectrally Similar To Pacific Blue, With Superior Photostability; Antibody Has Minimal Cross-Reactivity To Bovine, Horse, Human, And Rabbit Serum Proteins

Supplier: Biotium

Description: This antibody recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Supplier: Biotium

Description: CD31 / PECAM-1 Monoclonal antibody, Clone: C31.10, Host: Mouse, Conjugate: CF647, Species reactivity: Human, Immunogen: Recombinant human CD31 protein, Isotype: IgG1, kappa, Synonyms:EndoCAM; PECA1, GPIIA, Application: IF, IHC (formalin), FC, Size: 500 uL

Supplier: Biotium

Description: CD43Monoclonal antibody, Clone: DF-T1, Host: Mouse, Conjugate: CF405S, Species reactivity: Human, Isotype: IgG1, kappa, Immunogen: Myeloblastic KG1 cells, Synonyms: GALGP, GPL115, Application: IF, IHC, FC, Size: 500 uL

Supplier: Biotium

Description: This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Supplier: Biotium

Description: The MUC6 gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.