Anti-CD8a Rat Monoclonal Antibody [clone: 53-6.7] (APC)

Supplier: Stemcell Technologies
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60023AZ 60023AZ.1
MSPP-60023AZEA 553.92 USD
MSPP-60023AZ MSPP-60023AZ1
Anti-CD8a Rat Monoclonal Antibody [clone: 53-6.7] (APC)
Antibodies
Rat monoclonal IgG2a antibody against mouse, toad CD8a, APC-conjugated.

  • T cells
  • T cells CD8

The 53-6.7 antibody reacts with murine CD8a, a 32 - 34 kDa type I transmembrane glycoprotein which is a subunit of CD8. CD8 is a disulfide-bonded dimer, found either as a heterodimer of CD8a (α) and CD8b (β) subunits (i.e., αβ) or a homodimer (αα). CD8 acts as a co-receptor to the T cell receptor (TCR) during T cell activation by binding MHC Class I molecules presented by an antigen-presenting cell. It functions to strengthen the association between the TCR and MHC I-antigen complex and to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. The CD8a chain binds to the alpha-3 domain of class I MHC molecules. CD8 is expressed in the αβ form by a majority of thymocytes and a subset of mature peripheral blood T cells (T cytotoxic cells), and in the ββ form by γδ T cells, a subset of intestinal intraepithelial lymphocytes and dendritic cells. The 53-6.7 antibody reportedly blocks antigen presentation via MHC class I and inhibits IL-2-dependent T cell responses. This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse CD8+ T Cell Isolation Kit (Catalog #19853) and EasySep™ Mouse CD90.2 Positive Selection Kit II (Catalog #18951).

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD8a
Clonality: Monoclonal
Clone: 53-6.7
Conjugation: APC
Epitope:
Host: Rat
Isotype: IgG2a kappa
Reactivity: Mouse;Frog
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