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Supplier: Stemcell Technologies
Description: Immunomagnetic isolation of untouched human plasmacytoid dendritic cells (pDC)

Supplier: Stemcell Technologies
Description: Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma <i>et al.</i>). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau <i>et al.</i>). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).

Supplier: Stemcell Technologies
Description: Immunodensity isolation of untouched NK cells.

Catalog Number: (MSPP-18000)
Supplier: Stemcell Technologies
Description: The EasySep™ magnet is designed for cell separation procedures using EasySep™ reagents.


Supplier: Stemcell Technologies
Description: Immunomagnetic positive selection of CD90.2+ cells from mouse splenocytes or other tissues.

Supplier: Stemcell Technologies
Description: Immunomagnetic isolation of untouched human CD4+ T cells.

Catalog Number: (MSPP-05465)
Supplier: Stemcell Technologies
Description: For the in vitro differentiation of human MSCs into osteoblasts.


Catalog Number: (MSPP-19764)
Supplier: Stemcell Technologies
Description: Immunomagnetic isolation of untouched mouse plasmacytoid dendritic cells (pDC)


Catalog Number: (MSPP-17977)
Supplier: Stemcell Technologies
Description: Immunomagnetic negative selection kit.


Catalog Number: (MSPP-04436)
Supplier: Stemcell Technologies
Description: Serum-free methylcellulose-based medium with recombinant cytokines for human cells.


Catalog Number: (MSPP-05930)
Supplier: Stemcell Technologies
Description: Kit for generating iPS cells using ReproRNA™-OKSGM, a non-integrating, self-replicating RNA reprogramming vector.


Catalog Number: (MSPP-17846)
Supplier: Stemcell Technologies
Description: Immunomagnetic positive selection of human EpCAM+ cells (e.g. mammary epithelial cells).


Catalog Number: (MSPP-60103FI)
Supplier: Stemcell Technologies
Description: (C3H × BALB/c) F1 hybrid monoclonal IgG2a antibody against mouse NK1.1 (CD161).

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Supplier: Stemcell Technologies
Description: Mouse monoclonal IgG2a antibody against human, rhesus, cynomolgus CD184 (CXCR4), APC-conjugated.

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Supplier: Stemcell Technologies
Description: Rat monoclonal IgG2a antibody against mouse CD4, Alexa Fluor® 488-conjugated.

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Supplier: Stemcell Technologies
Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitors (Barreda <i>et al.</i>). GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 T cells (Francisco-Cruz <i>et al.</i>). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton <i>et al.</i>). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages <i>in vivo</i>. It has been tested for mobilization of hematopoietic progenitor cells and for treating chemotherapy-induced neutropenia in patients. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz <i>et al.</i>). This product is animal component-free.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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