Phorbol-12-myristate-13-acetate, Sigma-Aldrich®

Supplier: EMD MILLIPORE (BIOSCIENCES)
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524400-25MG 524400-1MG 524400-5MG 524400-10MG
80055-402EA 769.37 USD
80055-402 80055-400 80055-404 80055-398
Phorbol-12-myristate-13-acetate, Sigma-Aldrich®
Phorbol-12-myristate-13-acetate

Most commonly-used phorbol ester


Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the FAS antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.

Formula: C₃₆H₅₆O₈
MW: 616.836 g/mol
MDL Number: MFCD00036736
CAS Number: 16561-29-8

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