Anti-CGB Mouse Monoclonal Antibody (CF594) [clone: HCGb/54 HCGb/459]

Supplier: Biotium
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BNC941224-100 BNC941224-500
75951-816EA 205.77 USD
75951-816 75951-818
Anti-CGB Mouse Monoclonal Antibody (CF594) [clone: HCGb/54 HCGb/459]
Antibodies
This MAb reacts with a protein of 22 kDa, identified as β sub-unit of HCG. It does not cross react with the α sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The beta subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Type: Primary
Antigen: CGB
Clonality: Monoclonal
Clone: Clone HCGb/54 HCGb/459
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Human
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