Anti-PTH Mouse Monoclonal Antibody (CF488A) [clone: PTH/1173]

Supplier: Biotium
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BNC881173-100 BNC881173-500
75973-336EA 205.77 USD
75973-336 75973-338
Anti-PTH Mouse Monoclonal Antibody (CF488A) [clone: PTH/1173]
Antibodies
The epitope of this MAb maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: PTH
Clonality: Monoclonal
Clone: Clone PTH/1173
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
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