Anti-IDH1 Mouse Monoclonal Antibody (Biotin) [clone: IDH1/1152]

Supplier: Biotium

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BNCB1152-100 BNCB1152-500

75951-976EA 205.77 USD

75951-976 75951-978

Anti-IDH1 Mouse Monoclonal Antibody (Biotin) [clone: IDH1/1152]

Antibodies

This antibody recognizes a 45 kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming alpha-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of alpha-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

Type: Primary
Antigen: IDH1
Clonality: Monoclonal
Clone: Clone IDH1/1152
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1 andIgG2a, kappa
Reactivity: Human

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