Anti-TOX3 Mouse Monoclonal Antibody (CF405S) [clone: TOX3/1124]

Supplier: Biotium
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BNC041124-100 BNC041124-500
75977-476EA 205.77 USD
75977-476 75977-478
Anti-TOX3 Mouse Monoclonal Antibody (CF405S) [clone: TOX3/1124]
Antibodies
This antibody recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2 -dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Type: Primary
Antigen: TOX3
Clonality: Monoclonal
Clone: Clone TOX3/1124
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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