Anti-TOX3 Mouse Monoclonal Antibody (Biotin) [clone: TOX3/1123]

Supplier: Biotium

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BNCB1123-100 BNCB1123-500

75977-408EA 205.77 USD

75977-408 75977-410

Anti-TOX3 Mouse Monoclonal Antibody (Biotin) [clone: TOX3/1123]

Antibodies

This antibody recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2 -dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Type: Primary
Antigen: TOX3
Clonality: Monoclonal
Clone: Clone TOX3/1123
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human

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