Anti-TOX3 Mouse Monoclonal Antibody (CF647) [clone: TOX3/1123]

Supplier: Biotium
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BNC471123-100 BNC471123-500
75977-444EA 205.77 USD
75977-444 75977-446
Anti-TOX3 Mouse Monoclonal Antibody (CF647) [clone: TOX3/1123]
Antibodies
This antibody recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2 -dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Type: Primary
Antigen: TOX3
Clonality: Monoclonal
Clone: Clone TOX3/1123
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
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