Anti-CPS1 Mouse Monoclonal Antibody (CF594) [clone: CPS1/1022]

Supplier: Biotium
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BNC941022-100 BNC941022-500
75951-080EA 205.77 USD
75951-080 75951-082
Anti-CPS1 Mouse Monoclonal Antibody (CF594) [clone: CPS1/1022]
Antibodies
This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Type: Primary
Antigen: CPS1
Clonality: Monoclonal
Clone: Clone CPS1/1022
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Dog, Human
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