Anti-B2M Mouse Monoclonal Antibody (CF594) [clone: B2M/961]

Supplier: Biotium
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BNC940961-100 BNC940961-500
75884-270EA 205.77 USD
75884-270 75884-272
Anti-B2M Mouse Monoclonal Antibody (CF594) [clone: B2M/961]
Antibodies
This antibody recognizes a protein of 12 kDa, identified as β2-microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of analpha heavy chain that contains three subdomains (α1,alpha2,alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with thealpha3 subdomain of thealpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. Thealpha1 andalpha2 domains of thealpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Type: Primary
Antigen: B2M
Clonality: Monoclonal
Clone: Clone B2M/961
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human, Non-human primates
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