Anti-Melanoma Marker Mouse Monoclonal Antibody (CF488A) [clone: PNL2]

Supplier: Biotium
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BNC880894-100 BNC880894-500
75960-616EA 205.77 USD
75960-616 75960-618
Anti-Melanoma Marker Mouse Monoclonal Antibody (CF488A) [clone: PNL2]
Antibodies
Anti-PNL2 is a novel monoclonal antibody, which has recently been introduced as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. The antigen recognized by PNL2 is different from Melan A and gp100. Its epitope is not destroyed by digestion with neuraminidase i.e. its epitope id not glycosylated. Anti-PNL2 may be most useful because of its high sensitivity for metastatic melanoma (87%), as opposed to 76% for anti-HMB45 and 82% for anti-MART-1. Anti-PNL2 labels intra-epidermal nevi while the dermal component of compound nevi are largely non-reactive with anti-PNL2. Antibodies against PNL2, MART-1 (Melan A) and HMB45 stain most clear cell sarcoma cells and a few cells in angio-myolipomas and lymphangioleiomyomatosis. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, tyrosinase, and MiTF.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: Melanoma Marker
Clonality: Monoclonal
Clone: Clone PNL2
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Dog, Human, Mouse
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