Anti-BCL6 Mouse Monoclonal Antibody (CF594) [clone: BCL6/850]

Supplier: Biotium
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BNC940850-100 BNC940850-500
75885-018EA 205.77 USD
75885-018 75886-032
Anti-BCL6 Mouse Monoclonal Antibody (CF594) [clone: BCL6/850]
Antibodies
This antibody recognizes a protein of 95 kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Type: Primary
Antigen: BCL6
Clonality: Monoclonal
Clone: Clone BCL6/850
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Mouse
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