Anti-CCND1 Mouse Monoclonal Antibody (CF405S) [clone: CCND1/809]

Supplier: Biotium
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BNC040809-100 BNC040809-500
75925-004EA 205.77 USD
75925-004 75925-006
Anti-CCND1 Mouse Monoclonal Antibody (CF405S) [clone: CCND1/809]
Antibodies
This antibody recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Type: Primary
Antigen: CCND1
Clonality: Monoclonal
Clone: Clone CCND1/809
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human
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