Anti-PTPRC Mouse Monoclonal Antibody (CF488A) [clone: 2B11 PD7/26]

Supplier: Biotium
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BNC880745-100 BNC880745-500
75912-898EA 205.77 USD
75912-898 75912-900
Anti-PTPRC Mouse Monoclonal Antibody (CF488A) [clone: 2B11 PD7/26]
Antibodies
This antibody recognizes the CD45 leukocyte common antigen (LCA) family which comprises at least four isoforms of membrane glycoproteins (220, 205, 190, 180 kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portions of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. A positive result with this MAb is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: PTPRC
Clonality: Monoclonal
Clone: Clone 2B11 PD7/26
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Dog, Human
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