Anti-ITGAM Rat Monoclonal Antibody (Biotin) [clone: Clone M1/70]

Supplier: Biotium
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BNCB0720-100 BNCB0720-500
75886-310EA 205.77 USD
75886-310 75886-312
Anti-ITGAM Rat Monoclonal Antibody (Biotin) [clone: Clone M1/70]
Antibodies
CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. IntegrinalphaM combines with the Integrin beta2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). IntegrinalphaM/beta2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b and CD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.

Type: Primary
Antigen: ITGAM
Clonality: Monoclonal
Clone: Clone M1/70
Conjugation: Biotin
Epitope:
Host: Rat
Isotype: IgG2b kappa
Reactivity: Baboon, Chimpanzee, Human, Mouse, Rabbit, Rhesus monkey
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