Anti-ESR2 Mouse Monoclonal Antibody (CF488A) [clone: ESR2/686]

Supplier: Biotium
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BNC880686-100 BNC880686-500
75926-280EA 205.77 USD
75926-280 75926-282
Anti-ESR2 Mouse Monoclonal Antibody (CF488A) [clone: ESR2/686]
Antibodies
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: ESR2
Clonality: Monoclonal
Clone: Clone ESR2/686
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Human
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