Anti-KRT6A; KRT6B; KRT6C Mouse Monoclonal Antibody (CF594) [clone: LHK6]

Supplier: Biotium
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BNC940675-100 BNC940675-500
75920-000EA 205.77 USD
75920-000 75920-002
Anti-KRT6A; KRT6B; KRT6C Mouse Monoclonal Antibody (CF594) [clone: LHK6]
Antibodies
This MAb recognizes a protein of 56 kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Type: Primary
Antigen: KRT6A; KRT6B; KRT6C
Clonality: Monoclonal
Clone: Clone LHK6
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Mouse
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