Anti-TP53 Mouse Monoclonal Antibody (CF568) [clone: DO-7]

Supplier: Biotium
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BNC680513-100 BNC680513-500
75967-616EA 205.77 USD
75967-616 75967-618
Anti-TP53 Mouse Monoclonal Antibody (CF568) [clone: DO-7]
Antibodies
This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Type: Primary
Antigen: TP53
Clonality: Monoclonal
Clone: Clone DO-7
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Cow, Human, Monkey
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