Anti-ITGB4 Mouse Monoclonal Antibody (CF640R) [clone: UM-A9]

Supplier: Biotium
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BNC400449-100 BNC400449-500
75883-400EA 205.77 USD
75883-400 75883-402
Anti-ITGB4 Mouse Monoclonal Antibody (CF640R) [clone: UM-A9]
Antibodies
This antibody recognizes a protein of 205 kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Type: Primary
Antigen: ITGB4
Clonality: Monoclonal
Clone: Clone UM-A9
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human
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