Anti-CTNNB1 Rabbit Polyclonal Antibody (CF647)

Supplier: Biotium
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

BNC470376-100 BNC470376-500
75980-400EA 205.77 USD
75980-400 75980-402
Anti-CTNNB1 Rabbit Polyclonal Antibody (CF647)
Antibodies
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Type: Primary
Antigen: CTNNB1
Clonality: Polyclonal
Clone:
Conjugation: CF647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR