Anti-TLR4 Mouse Monoclonal Antibody (CF488A) [clone: TLR4/230]

Supplier: Biotium
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BNC880230-100 BNC880230-500
75892-006EA 205.77 USD
75892-006 75892-008
Anti-TLR4 Mouse Monoclonal Antibody (CF488A) [clone: TLR4/230]
Antibodies
This MAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: TLR4
Clonality: Monoclonal
Clone: Clone TLR4/230
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Dog, Guinea Pig, Human, Monkey, Pig, Rat
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