Anti-HLA-DQ Mouse Monoclonal Antibody (Biotin) [clone: SPV-L3]

Supplier: Biotium
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: 0.0 out of 5

BNCB0200-100 BNCB0200-500
75961-060EA 230.25 USD
75961-060 75961-062
Anti-HLA-DQ Mouse Monoclonal Antibody (Biotin) [clone: SPV-L3]
Antibodies
This antibody recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.

Type: Primary
Antigen: HLA-DQ
Clonality: Monoclonal
Clone: Clone SPV-L3
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human, Pig
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR