Anti-FOXP3 Mouse Monoclonal Antibody (CF640R) [clone: FXP3/197]

Supplier: Biotium
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BNC400197-100 BNC400197-500
75927-256EA 205.77 USD
75927-256 75927-258
Anti-FOXP3 Mouse Monoclonal Antibody (CF640R) [clone: FXP3/197]
Antibodies
This antibody recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Type: Primary
Antigen: FOXP3
Clonality: Monoclonal
Clone: Clone FXP3/197
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Monkey, Mouse
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