Anti-B2M Mouse Monoclonal Antibody (CF405S) [clone: BBM.1]

Supplier: Biotium
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BNC040142-100 BNC040142-500
75883-954EA 205.77 USD
75883-954 75883-956
Anti-B2M Mouse Monoclonal Antibody (CF405S) [clone: BBM.1]
Antibodies
This antibody recognizes a protein of 12 kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Type: Primary
Antigen: B2M
Clonality: Monoclonal
Clone: Clone BBM.1
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human, Non-human primates
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