Human NMNAT3 (from E. coli), AdipoGen Life Sciences

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AG-40T-0093-C010 AG-40T-0093-C050 AG-40T-0093-3050

102980-430EA 290.77 USD

102980-430 102980-432 102980-434

Human NMNAT3 (from E. coli), AdipoGen Life Sciences

Enzymes

Mitochondrial NMNAT isoform

UniProt link Q96T66: NMNAT3 (human)

Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. Can use tiazofurin monophosphate as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, mitochondrial NMNAT isoform can use NAD(+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+. Protects against axonal degeneration following injury.

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