Momelotinib ≥97% (by HPLC)

Supplier: SAFE AND SURE NEDERLAND B.V.
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CHM197-0001 CHM197-0005
76003-242EA 70.9 USD
76003-242 76003-244
Momelotinib ≥97% (by HPLC)
Momelotinib

Selective inhibitor of JAK1 and JAK2 kinases including the JAK2 V617F mutant


Using ATP kinase assays, the IC50 values for CYT387 are a follows - JAK1 (11nM), JAK2, (18nM), JAK2 V617F (23nM) JAK3 (155nM), and TYK2 (17nM). In testing kinase arrays, CYT387 also had activity (defined as an IC50 < 100nM) detected against CDK2/cyclin A, MAPK8 (JNK1), PRKCN (PKD3), PRKD1 (PKCμ), ROCK2, and TBK1 kinase as well.

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