LEE011 ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste

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SYN-1213-M001 SYN-1213-M005 SYN-1213-M010 SYN-1213-M050 SYN-1213-M100

102992-820EA 74.77 USD

102992-820 102992-822 102992-824 102992-826 102992-828

LEE011 ≥95%

LEE011

Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

Formula: C₂₃H₃₀N₈O
MW: 434.5 g/mol
Storage Temperature: Freezer

MDL Number: MFCD27976795
CAS Number: 1211441-98-3

Specification Test Results

Purity	95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO.

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